ArticleEuropean journal of dentistry2026
Enhancing the Odontogenic Potential of Human Dental Pulp Stem Cells via Platelet-Rich Plasma Exosomes through Modulation of TGF-β1 and Dentin Sialophosphoprotein.
Article in European journal of dentistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The trial behind it
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Who cites it
3 citing papers in PubMed.
- Exosome-loaded human amniotic membrane hydrogel modulates regenerative responses of human dental pulp stem cells.Journal of conservative dentistry and endodontics · 2026Article
- Comparative Analysis of Different Origin-Derived Exosomes for Future Regenerative Endodontic Therapies: A Systematic Review.Clinical, cosmetic and investigational dentistry · 2026Review
- Wharton's jelly mesenchymal stem cell-derived exosomes promote odontogenic differentiation of dental pulp stem cells: A cell-free strategy for regenerative endodontics.Journal of conservative dentistry and endodontics · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: Although platelet-rich plasma (PRP) has demonstrated considerable regenerative potential in regenerative endodontic treatment, its clinical efficacy may be limited by the rapid degradation of its bioactive components, leading to inconsistent outcomes. To overcome this challenge, the present study explores the use of nano-sized exosomes derived from PRP-a novel designated as PRP exosomes (PRP-Exo)-as a more stable and targeted biomolecular delivery system to promote odontogenic differentiation within the dentin-pulp complex. The primary objective is to investigate the expression of key odontogenic markers, transforming growth factor-β1 (TGF-β1) and Dentin Sialophosphoprotein (DSPP), in human dental pulp stem cells (hDPSCs) following PRP-Exo treatment. Materials and Methods: hDPSCs used in this study were biologically stored raw cells harvested at P3-P4. The hDPSCs were starved for 24 hours, then isolated and re-cultured using the enzymatic digestion method until reaching 5 × 10 Results: From the NTA result, it was shown that PRP-Exo, which was isolated in this study, has a particle size range of 30 to 150 nm, a homogeneous shape of particles, with several particles after dilution (1.2 × 10 Conclusion: The higher expression of TGF-β1 and DSPP and a larger amount of Ca
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Registered trials
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