Evidence map›Paper›PMID 40921167›Full record

ArticleAmerican journal of perinatology2026

Adverse Pregnancy Outcomes in Patients with Congenital Uterine Anomalies: Evaluation of a Population Dataset.

Zoe O Silsby, Jessica Abou Zeki, Anna Swensen, Stephen Rhodes, David C Kaelber, David Sheyn, Justin R Lappen

Abstract read
In one paragraph

Article in American journal of perinatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Zoe O SilsbyCase Western Reserve University School of Medicine, Cleveland, Ohio, United States.
Jessica Abou ZekiDepartment of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States.
Anna SwensenCase Western Reserve University School of Medicine, Cleveland, Ohio, United States.
Stephen RhodesDepartment of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States.
David C KaelberDepartments of Internal Medicine, Pediatrics, and Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, Ohio, United States.
David SheynDepartment of Urology, University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States.
Justin R LappenDivision of Maternal and Fetal Medicine, OB/GYN and Women's Health Institute, Cleveland Clinic, Cleveland, Ohio, United States.

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5M
Clinical and Translational Science Collaborative of Northern Ohio, Catalyzing Linkages to Equity in Health (CLE Health)UM1TR004528 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI GRACE A MCCOMSEY · 2023 to 2026
$32.1M
NCATS NIH HHS UL1 TR002548NCATS NIH HHS UM1 TR004528
6 · The paper itself

Abstract

This study aimed to characterize the risk of adverse pregnancy outcomes among patients with congenital uterine anomalies (CUA) using electronic health record data.Retrospective cohort study utilizing the TriNetX analytics research network, including female patients aged 10 to 55 with a documented singleton and intrauterine pregnancy.A total of 561,440 patients met inclusion criteria, of whom 3,381 (0.6%) had one or more International Classification of Diseases (ICD) encounter diagnosis codes for CUA. Compared with patients with no documented ICD encounter diagnosis of CUA, patients with CUA had lower rates of live birth (odds ratio [OR]: 0.36, 95% confidence interval [CI]: 0.33-0.38). CUA patients had higher rates of preterm labor (OR: 1.41, 95% CI: 1.20-1.65), fetal malpresentation (OR: 2.48, 95% CI: 2.16-2.85), and postpartum hemorrhage (OR: 1.54, 95% CI: 1.31-1.80). Severe maternal morbidity (SMM) was increased in patients with CUA, including for hysterectomy (OR: 3.41, 95% CI: 1.26-9.17) and acute renal failure (OR: 1.97, 95% CI: 1.08-3.57).Patients with CUA are at higher risk of adverse pregnancy outcomes compared with patients with normal uterine anatomy, including for SMM and postpartum complications. These patients should be counseled about these possible risks, and CUA should be incorporated into risk-stratification and prevention strategies. · Adversary pregnancy outcomes are higher with CUAs.. · CUA patients have higher risk of preterm delivery.. · CUAs are linked to higher rates of fetal malpresentation.. · Markers of SMM increased in patients with CUA.. · Enhanced screening and high-risk delivery care are encouraged..

Indexed as

Pregnancy ComplicationsPregnancy OutcomeUrogenital AbnormalitiesUterusAdolescentAdultChildElectronic Health RecordsFemaleHumansHysterectomyMiddle AgedObstetric Labor, PrematurePostpartum HemorrhagePregnancyPremature Birth

Identifiers

PMID40921167
PMCPMC13521620

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.