Evidence map›Paper›PMID 40921080›Full record

ArticleJournal of medicinal chemistry2025

Structure-Activity Relationships of 3-Hydroxypropanamidines (HPAs) with Potent In Vivo Antimalarial Activity.

Saskia Klein, Alena Moritz, Lais Pessanha de Carvalho, Tanja C Knaab, Beate Lungerich, Lukas Meyer, Jona Sandström, Jessica L Thibaud, Katherine A de Villiers, David A Fidock and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of medicinal chemistry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Saskia KleinFaculty of Mathematics and Natural Sciences, Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Alena MoritzIndividualized Pharmacotherapy, Institute of Pharmaceutical and Medicinal Chemistry, University of Muenster, 48149 Muenster, Germany.
Lais Pessanha de CarvalhoInstitute of Tropical Medicine, Eberhard Karls University Tuebingen, 72074 Tuebingen, Germany.
Tanja C KnaabDepartment of Pharmacy, Ludwig Maximilians University München, 81377 München, Germany.
Beate LungerichIndividualized Pharmacotherapy, Institute of Pharmaceutical and Medicinal Chemistry, University of Muenster, 48149 Muenster, Germany.
Lukas MeyerFaculty of Mathematics and Natural Sciences, Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Jona SandströmFaculty of Mathematics and Natural Sciences, Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.
Jessica L ThibaudDepartment of Chemistry and Polymer Science, Stellenbosch University, Matieland 7602, South Africa.
Katherine A de VilliersDepartment of Chemistry and Polymer Science, Stellenbosch University, Matieland 7602, South Africa.ORCID 0000-0002-2932-395X
David A FidockDepartment of Microbiology and Immunology and Center for Malaria Therapeutics and Antimalarial Resistance, Division of Infectious Diseases, Department of Medicine, Columbia University Irving Medical Center, New York, New York 10032, United States.
Sergio WittlinSwiss Tropical and Public Health Institute, Allschwil CH-4123, Switzerland.ORCID 0000-0002-0811-0912
Matthias RottmannSwiss Tropical and Public Health Institute, Allschwil CH-4123, Switzerland.
Jana HeldInstitute of Tropical Medicine, Eberhard Karls University Tuebingen, 72074 Tuebingen, Germany.ORCID 0000-0002-7970-1429
Bjoern B BurckhardtIndividualized Pharmacotherapy, Institute of Pharmaceutical and Medicinal Chemistry, University of Muenster, 48149 Muenster, Germany.ORCID 0000-0002-1782-9937
Thomas KurzFaculty of Mathematics and Natural Sciences, Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, 40225 Düsseldorf, Germany.ORCID 0000-0002-9474-4224

Funding

Defining the complex genetic basis of Plasmodium falciparum resistance to artemisinin and quinine and identifying resistance-refractory therapeuticsR01AI185559 · NIAID · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI David A Fidock · 2024 to 2026
$1.9M
NIAID NIH HHS R01 AI185559
6 · The paper itself

Abstract

New treatment strategies are required to combat the spread of drug-resistant

Indexed as

AmidinesAntimalarialsPlasmodium falciparumAnimalsHep G2 CellsHumansMalariaMiceParasitic Sensitivity TestsPlasmodium bergheiRatsStructure-Activity RelationshipAmidinesAntimalarials

Identifiers

PMID40921080
PMCPMC12888999

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.