Evidence map›Paper›PMID 40920799›Full record

Observational studyPloS one2025

Interferon-gamma 1b-induced gene expression alters neutrophil function in patients with chronic granulomatous disease.

Daniel R Ambruso, Natalie J Briones, Alexander D Tran, Bridget Sanford, Christine Childs, Ben Z Katz, Michael Ellison, Richard B Johnston, Kenneth L Jones

Registry-linked trialAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03548818 (Role of Interferon-gamma 1-b), which is not on this map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03548818 completednot on this map

Role of Interferon-gamma 1-b (IFN-γ) on Cells of the Innate Immune System: Functional, Biochemical and Gene Expression Studies in Patients With Chronic Granulomatous Disease

TypeobservationalSponsorUniversity of Colorado, DenverRan2018 to 2020Enrolled9ConditionsChronic Granulomatous DiseaseArmsInterferon Gamma-1B
3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. How I Treat: Chronic granulomatous disease.Journal of human immunity · 2026
    Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Daniel R AmbrusoDepartment of Pediatrics University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America.ORCID 0000-0001-7049-354X
Natalie J BrionesDepartment of Pediatrics University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America.
Alexander D TranDepartment of Pediatrics University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America.
Bridget SanfordDepartment of Pediatrics University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America.ORCID 0000-0002-2173-0198
Christine ChildsUniversity of Colorado Cancer Center Flow Cytometry Shared Resource, Anschutz Medical Campus, Aurora, Colorado, United States of America.
Ben Z KatzNorthwestern University Feinberg School of Medicine, Department of Pediatrics and Division of Infectious Diseases, Anna and Robert H. Lurie Children's Hospital of Chicago, Chicago, Illinois, United States of America.ORCID 0000-0003-0149-2388
Michael EllisonDepartment of Pediatrics University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America.
Richard B JohnstonDepartment of Pediatrics University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America.
Kenneth L JonesDepartment of Pediatrics University of Colorado Denver, Anschutz Medical Campus, Aurora, Colorado, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

trial registrationClinicalTrials.gov NCT03548818.

Indexed as

Gene Expression RegulationGranulomatous Disease, ChronicInterferon-gammaNeutrophilsAdultFemaleHumansMaleInterferon-gamma

Identifiers

PMID40920799
PMCPMC12416707

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.