Evidence map›Paper›PMID 40920663›Full record

ArticleAmerican journal of physiology. Cell physiology2025

(R)-vanzacaftor potentiates BK

Aaron Kolski-Andreaco, Scott A Hahn, John Sembrat, Adam C Straub, Michael B Butterworth, Daniel C Devor

Abstract read
In one paragraph

Article in American journal of physiology. Cell physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Aaron Kolski-AndreacoDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
Scott A HahnDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.
John SembratDivision of Pulmonary, Allergy, Critical Care and Sleep Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0003-4108-803X
Adam C StraubDepartment of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0003-0542-9466
Michael B ButterworthDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0002-2173-8333
Daniel C DevorDepartment of Cell Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, United States.ORCID 0000-0003-3013-5179

Funding

Basic and Translational Studies in Redox Regulation of Cardiovascular Physiology and DiseaseR35HL161177 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Adam Carl Straub · 2022 to 2026
$4.7M
Role of MicroRNAs in Kidney Sodium RegulationR01DK102843 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BUTTERWORTH, MICHAEL B · 2015 to 2024
$3.6M
Modulation of Ca2+ -activated K+ channels by CFTR CorrectorsR01HL171413 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DANIEL C DEVOR · 2024 to 2026
$1.8M
Cystic Fibrosis Foundation (CFF) CFF RDPHHS | National Institutes of Health (NIH) DK102843HHS | National Institutes of Health (NIH) HL171413NHLBI NIH HHS R01 HL171413NHLBI NIH HHS R35 HL161177NIDDK NIH HHS R01 DK102843
6 · The paper itself

Abstract

We previously demonstrated the CFTR correctors VX-445 (elexacaftor) and S-VX-121 (vanzacaftor) potentiate heterologously expressed BK

Indexed as

Cystic Fibrosis Transmembrane Conductance RegulatorIndolesLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsPyrazolesPyrrolidinesAnimalsEpithelial CellsHumansMaleMicePyridinesRatsRats, Inbred F344CFTR protein, humanCystic Fibrosis Transmembrane Conductance RegulatorelexacaftorIndolesLarge-Conductance Calcium-Activated Potassium Channel alpha SubunitsPyrazolesPyridinesPyrrolidinesBKCaCFTRcystic fibrosisvanzacaftorvasodilation

Identifiers

PMID40920663
PMCPMC12621279

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.