Evidence map›Paper›PMID 40920602›Full record

ArticleOrganic letters2025

Asymmetric Synthesis of Cycloartobiloxanthone.

Cheng-En Hsieh, Sarah N Dishman, Christine A Dimirjian, Linda Ung, Tony E Dorado, Jenna C Molas, Jose A Maldonado, James C Fettinger, Jared T Shaw

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Organic letters, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Cheng-En HsiehDepartment of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.ORCID 0009-0009-8975-3941
Sarah N DishmanDepartment of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.
Christine A DimirjianDepartment of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.ORCID 0000-0002-8666-1576
Linda UngDepartment of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.
Tony E DoradoDepartment of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.
Jenna C MolasDepartment of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.
Jose A MaldonadoDepartment of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.
James C FettingerDepartment of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.ORCID 0000-0002-6428-4909
Jared T ShawDepartment of Chemistry, University of California, Davis, One Shields Avenue, Davis, California 95616, United States.ORCID 0000-0001-5190-493X

Funding

Supplement: Studies in the Synthesis of Complex Organic Molecules with Donor-Donor CarbenesR35GM149209 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Jared Thomas Shaw · 2023 to 2026
$1.8M
NIGMS NIH HHS R35 GM149209
6 · The paper itself

Abstract

Herein, we report the first asymmetric synthesis of cycloartobiloxanthone, a polycyclic dihydroxanthone natural product. Our convergent synthesis employs a rhodium-catalyzed C-H insertion reaction to construct the key fused tricyclic core with high enantioselectivity. Two fragments were joined together by a displacement reaction and a Friedel-Crafts acylation to generate the dihydroxanthone core. This synthesis offers a promising foundation for accessing structurally related dihydroxanthone natural products and analogues for structure-activity relationship studies.

Identifiers

PMID40920602
PMCPMC13155250

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.