Evidence map›Paper›PMID 40920493›Full record

ArticleMicrobiology spectrum2025

Global transcriptomics and targeted metabolite analysis reveal the involvement of the AcrAB efflux pump in physiological functions by exporting signaling molecules in

Linda Hadchity, Anne Lanois-Nouri, Adrien Chouchou, David Roche, Jessica Houard, Noémie Claveyroles, Alexandra Dauvé, Jacques Imbert, Maxime Gualtieri, Alain Givaudan and 2 more

Abstract read
In one paragraph

Article in Microbiology spectrum, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Linda HadchityDGIMI, INRAE, Université Montpellier, Montpellier, France.ORCID 0009-0002-1589-6383
Anne Lanois-NouriDGIMI, INRAE, Université Montpellier, Montpellier, France.ORCID 0009-0007-4075-7058
Adrien ChouchouIBMM, Université Montpellier, CNRS, ENSCM, Montpellier, France.ORCID 0000-0002-2061-4670
David RocheGénomique Métabolique, Genoscope, Institut François Jacob, CEA, CNRS, Univ Evry, Université Paris-Saclay, Evry, France.
Jessica HouardNosopharm, Nîmes, France.
Noémie ClaveyrolesDGIMI, INRAE, Université Montpellier, Montpellier, France.
Alexandra DauvéMGX-Montpellier GenomiX, c/o IGF, Montpellier, France.
Jacques ImbertMGX-Montpellier GenomiX, c/o IGF, Montpellier, France.
Maxime GualtieriNosopharm, Nîmes, France.ORCID 0000-0001-6590-2468
Alain GivaudanDGIMI, INRAE, Université Montpellier, Montpellier, France.ORCID 0000-0002-3901-5133
Alyssa Carré-MloukaDGIMI, INRAE, Université Montpellier, Montpellier, France.ORCID 0000-0002-6141-8115
Ziad Abi KhattarFaculty of Medicine and Medical Sciences, University of Balamand, Tripoli, Lebanon.ORCID 0000-0003-4386-7467

Funding

Agence Nationale de la Recherche PlandeRelance_MolchecoInstitut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement IB2023PHC_cedre_2022 N47846_ZEUniversité Libanaise Grant_2022-2023
6 · The paper itself

Abstract

In Gram-negative bacteria, resistance-nodulation-division (RND)-type efflux pumps, particularly AcrAB-TolC, play a critical role in mediating resistance to antimicrobial agents and toxic metabolites, contributing to multidrug resistance.

Indexed as

Bacterial ProteinsMembrane Transport ProteinsPhotorhabdusTranscriptomeGene Expression ProfilingGene Expression Regulation, BacterialSignal TransductionBacterial ProteinsMembrane Transport Proteinsefflux pumpPhotorhabduspleiotropysignaling moleculesspecialized metabolitestargeted metabolite analysistranscriptional regulation

Identifiers

PMID40920493
PMCPMC12502680

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.