Evidence map›Paper›PMID 40920313›Full record

ArticleIrish journal of medical science2025

A study of tertiary hyperparathyroidism.

Bhoomika Venkateshappa, Prasanna Narayanaswamy, Koti Reddy Kandula Venkata, Gurupriya Madupuri, Varalakshmi Boreddy, Aiswarya Lakshmi Pavuluri, Rapur Ram, Siva Kumar Vishnubotla

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Article in Irish journal of medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Bhoomika VenkateshappaSri Venkateswara Institute of Medical Sciences, Tirupati, India.
Prasanna NarayanaswamySri Venkateswara Institute of Medical Sciences, Tirupati, India.
Koti Reddy Kandula VenkataSri Venkateswara Institute of Medical Sciences, Tirupati, India.
Gurupriya MadupuriSri Venkateswara Institute of Medical Sciences, Tirupati, India.
Varalakshmi BoreddySri Venkateswara Institute of Medical Sciences, Tirupati, India.
Aiswarya Lakshmi PavuluriSri Venkateswara Institute of Medical Sciences, Tirupati, India.
Rapur RamSri Venkateswara Institute of Medical Sciences, Tirupati, India. ram_5_1999@yahoo.com.
Siva Kumar VishnubotlaSri Venkateswara Institute of Medical Sciences, Tirupati, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionInformation on tertiary hyperparathyroidism (THPTH) among chronic kidney disease (CKD) patients on haemodialysis in developing countries such as India is limited, and the mortality among them remains a query. MATERIALS AND

methodsThis was a prospective cohort study conducted in at a tertiary care centre from June 2017 to June 2022. The index of suspicion for tertiary hyperparathyroidism was when investigations revealed high serum calcium and high alkaline phosphatase along with new onset of body aches, joint pains, and difficulty in walking. Patients, with above clinical features, were considered for 99 m Tc-Sestamibi scan and high-resolution ultrasound of the neck, when serum parathormone was > 600 pg/mL. Those patients diagnosed with tertiary hyperparathyroidism were followed up for 5 years.

resultsThe incidence of tertiary hyperparathyroidism among CKD patients was 13.4%. The mean age of CKD stage 5 patients with tertiary hyperparathyroidism was 55.17 ± 11.1 years. The observation from our study was the mean survival time among patients who underwent parathyroidectomy and among patients who received cinacalcet was almost similar, whereas the mean survival time among patients who received phosphate binders was lower. However, the survival rate among patients on cinacalcet and who underwent parathyroidectomy were not statistically significant. DISCUSSION: There were no cross-sectional studies on prevalence of tertiary hyperparathyroidism in India as per our knowledge, although the prospective design, large sample size, PTH stratification, and frequent measurements of a comprehensive panel of mineral metabolites are strengths of the current study.

Indexed as

HyperparathyroidismRenal Insufficiency, ChronicAdultAgedAlkaline PhosphataseCalciumCinacalcetFemaleHumansIndiaMaleMiddle AgedParathyroidectomyParathyroid HormoneProspective StudiesRenal DialysisAlkaline PhosphataseCalciumCinacalcetParathyroid HormoneCinacalcetParathyroidectomyPhosphate bindersTc-99 sestamibi scanTertiary hyperparathyroidism

Identifiers

PMID40920313

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