ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2026
Cerebral autoregulation in orthostatic hypotension and falls among older adults: a community-based exploratory study.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Beyond haemodynamic monitoring: symptom-based autonomic assessment in falls risk evaluation.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Timing of Orthostatic Blood Pressure Changes and Its Association With Orthostatic Symptoms and Falls at Very Old Ages: Findings From the ARIC Study.Hypertension (Dallas, Tex. : 1979) · 2026Article
- A Closed-Loop Cardiovascular Model of the Supine-To-Stand Manoeuvre: Implications for Falls.International journal for numerical methods in biomedical engineering · 2026Article
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4 authors.
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Abstract
backgroundOrthostatic hypotension (OH) is prevalent in older adults and is often associated with falls. However, the presence or absence of symptoms in OH may be mediated by cerebral autoregulation, which helps maintain cerebral perfusion during blood pressure fluctuations.
methodsWe recruited 40 older adults (aged ≥ 55 years) from the Malaysian Elders Longitudinal Research (MELoR) cohort. Participants underwent cerebral blood flow velocity monitoring using transcranial Doppler ultrasonography and beat-to-beat blood pressure recording. Three protocols were used: active stand, mental arithmetic, and Valsalva manoeuvre. Participants were categorized, based on OH (≥ 30 mmHg systolic drop) and fall history, into four groups. Cerebrovascular resistance (CVR) was derived and analysed.
resultsParticipants with OH but no history of falls demonstrated preserved autoregulatory responses, as reflected by adaptive reductions in CVR. In contrast, fallers-regardless of OH status-had impaired CVR modulation. Significant group differences were found during the active stand test at 165 s and 180 s (p < 0.05).
conclusionPreserved cerebral autoregulation may protect older adults with OH from symptomatic manifestations such as falls. Targeting cerebral autoregulation could offer novel approaches for preventing falls in this population.
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