ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2025
G20 stroke burden 1990-2035: trends, projections and precision health insights.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Systematic review of gut microbiota structural characteristics in patients with ischemic stroke.Frontiers in cellular and infection microbiology · 2026Pooled it
- Burden trends and disparities of metabolic risk-attributable peripheral arterial disease in China (1990-2035): a comparative analysis with G20 countries.International journal of public health · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundStroke persists as the second leading global cause of mortality and disability. We analyzed G20 nations using Global Burden of Disease (GBD) 2021 data (1990-2021) to provide a new perspective.
methodsWe obtained age-standardized rates (ASR) of stroke mortality, incidence, prevalence, and YLLs (years of life lost) across G20 nations. Attributable risks identified key factors, decomposition analysis explored epidemiological drivers, and inequality analysis assessed socioeconomic disparities. Bayesian age-period-cohort (BAPC) modeling projected trends to 2035.
resultsIn 2021, stroke was the second leading cause of level 3 mortality in the G20 countries, accounting for 11.83% (95% UI:10.75-12.59) of total deaths, and the leading cause of level 3 mortality in China and Indonesia. In 2021, stroke caused 5.27 million (4.67-5.78) deaths in the G20 countries, with 8.74 million (7.80-9.77) new cases and 67.82 million (63.67-72.51) prevalent cases, the years of life lost (YLLs) totaled 100.63 million (91.46-110.31). China had the highest absolute burden; Indonesia showed the highest ASMR (Age-standardized mortality rates), ASIR (Age-standardized incidence rates), ASPR (age-standardized prevalence rates), and ASYR (age-standardized years of life lost), South Korea had the steepest ASR declines. High systolic blood pressure and air pollution were primary risk factors. Projections reveal Indonesia's rapid ASR declines contrasting with China's rising prevalence among adults ≥ 75 years and growing case numbers in aging populations.
conclusionsWhile stroke ASR decreased significantly since 1990, substantial cross-country disparities persist, linked to socioeconomic development. Absolute burden will increase with aging populations, necessitating targeted interventions against hypertension, air pollution, and elderly healthcare gaps.
Indexed as
Identifiers
40920252What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.