Evidence map›Paper›PMID 40920242›Full record

ArticleJournal of neurology2025

Construct validity, intrarater and interrater reliability of the Italian version of the systematic screening of handwriting difficulties (SOS) test in people with Parkinson's disease.

Davide Corbetta, Elisabetta Sarasso, Andrea Gardoni, Lucia Zenere, Roberta Balestrino, Bouwien Smits-Engelsman, Elisa Pelosin, Massimo Filippi, Federica Agosta

Registry-linked trialAbstract readValidation Study
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04876352 (Clinical and Brain Functional MRI Effects of a Rehabilitative Training of Upper Limb Using Immersive Virtual Reality in People With Parkinson's Disease), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04876352 nacompletednot on this map

Clinical and Brain Functional MRI Effects of a Rehabilitative Training of Upper Limb Using Immersive Virtual Reality in People With Parkinson's Disease

TypeinterventionalSponsorProf. Massimo FilippiRan2021 to 2024Enrolled70ConditionsParkinson DiseaseArmsUpper limb/handwriting exercises in an immersive virtual reality setting (VR-training), Upper limb/handwriting exercises in a real setting (RS-training), No intervention
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Davide CorbettaDepartment of Rehabilitation and Functional Recovery, IRCCS San Raffaele Scientific Institute, Milan, Italy. corbetta.davide@hsr.it.ORCID http://orcid.org/0000-0003-3981-7248
Elisabetta SarassoNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0002-5300-2849
Andrea GardoniNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0002-2189-5689
Lucia ZenereNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0009-0009-4992-1154
Roberta BalestrinoNeurotech Hub, Vita-Salute San Raffaele University, Milan, Italy.ORCID http://orcid.org/0000-0001-7143-6985
Bouwien Smits-EngelsmanPhysical Activity, Sport and Recreation (PhASRec), Faculty of Health Sciences, North-West University, Potchefstroom, 2531, South Africa.ORCID http://orcid.org/0000-0003-0632-3276
Elisa PelosinDepartment of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal Child Health, University of Genoa, Genoa, Italy.ORCID http://orcid.org/0000-0002-9880-2241
Massimo FilippiNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0002-5485-0479
Federica AgostaNeuroimaging Research Unit, Division of Neuroscience, IRCCS San Raffaele Scientific Institute, Milan, Italy.ORCID http://orcid.org/0000-0003-3121-4979

Funding

Ministero della Salute GR-2018-12366005
6 · The paper itself

Abstract

backgroundThe "Systematic Screening of Handwriting Difficulties in Parkinson's Disease" (SOS) test is the only tool specifically designed to evaluate handwriting in people with Parkinson's Disease (pwPD). It is language specific.

objectiveTo assess the construct validity, intrarater and interrater reliability of the Italian version of the SOS test.

methodsThirty-five pwPD and 15 healthy controls (HC) completed the Italian version of the SOS test. Participants copied an Italian text for 5 min on blank paper using a pen. Two independent raters evaluated writing speed, letter size, and handwriting quality according to the SOS test criteria. Correlations between the Italian SOS test scores, fine motor skills, and PD characteristics were analysed using Spearman's Rho correlation coefficient (ρ). Group comparisons were adjusted for education level using ANCOVA. Intrarater and interrater reliability were calculated using the intraclass correlation coefficient (ICC) or Kendall's Tau (Kτ) coefficient depending on data distribution.

resultsThe Italian version of the SOS test showed significant correlations between writing speed and fine motor skills in pwPD (ρ = 0.40; p = 0.016). PwPD showed significantly smaller letter size (η

conclusionThe Italian version of the SOS test is a valid and reliable tool for clinically assessing handwriting in Italian-speaking pwPD. CLINICAL

trial registrationhttps://clinicaltrials.gov/ : NCT04876352, prospectively registered on May 6th 2021.

Indexed as

HandwritingMotor SkillsParkinson DiseaseAgedFemaleHumansItalyMaleMiddle AgedObserver VariationRandomized Controlled Trials as TopicReproducibility of ResultsHandwritingParkinson’s diseaseValidation study

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.