Evidence map›Paper›PMID 40920082›Full record

ArticleJournal of virology2025

Limiting viral replication in hematopoietic cells delays Rift Valley fever virus disease progression in C57BL/6 mice.

Lingqing Xu, Alden C Paine, Dominique J Barbeau, William Klimstra, Anita K McElroy

Abstract read
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Lingqing XuDivision of Pediatric Infectious Disease, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-6451-1673
Alden C PaineDivision of Pediatric Infectious Disease, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Dominique J BarbeauDivision of Pediatric Infectious Disease, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-6493-5022
William KlimstraCenter for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Anita K McElroyDivision of Pediatric Infectious Disease, Department of Pediatrics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.ORCID 0000-0001-6764-7536

Funding

Practices CoreUC7AI180311 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI William Paul Duprex · 2023 to 2026
$13.2M
Viral Persistence and PathogenesisT32AI049820 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI DELUCA, NEAL A. · 2001 to 2024
$5.5M
An Informed Approach to Live Attenuated Vaccines against Encephalitis AlphavirusesR01AI153209 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLIMSTRA, WILLIAM B · 2020 to 2024
$2.9M
Innate immune recognition and response to Rift Valley fever virusR01AI171200 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Anita K McElroy · 2022 to 2026
$2.2M
National Institute of Allergy and Infectious Diseases R01AI153209National Institute of Allergy and Infectious Diseases R01AI171200NIAID NIH HHS R01 AI153209NIAID NIH HHS R01 AI171200NIAID NIH HHS T32 AI049820NIAID NIH HHS UC7 AI180311
6 · The paper itself

Abstract

Rift Valley fever virus (RVFV) causes mild to severe disease in livestock and humans. It was first identified in 1931 during an epizootic in Kenya and has spread across Africa and into the Middle East. Hematopoietic cells are one of the major targets of RVFV

Indexed as

Hematopoietic Stem CellsMicroRNAsRift Valley FeverRift Valley fever virusVirus ReplicationAnimalsDisease ProgressionFemaleMiceMice, Inbred C57BLMicroRNAsMirn142 microRNA, mousehematopoietic cellsmicroRNARift Valley fever virustype I IFNviral pathogenesis

Identifiers

PMID40920082
PMCPMC12548454

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.