Evidence map›Paper›PMID 40920032›Full record

ReviewmBio2025

Reprogramming resistance: phage-antibiotic synergy targets efflux systems in ESKAPEE pathogens.

Anita Tarasenko, Bhavya N Papudeshi, Susanna R Grigson, Vijini Mallawaarachchi, Abbey L K Hutton, Morgyn S Warner, Jeremy J Barr, Jon Iredell, Bart Eijkelkamp, Robert A Edwards

Abstract readReview
In one paragraph

Review in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed.

  1. Review
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  5. Article
  6. Article
  7. From screening to treatment:Microbiology spectrum · 2026
    Article
  8. Giving Antibiotics a Second Chance: Evolutionary Trade-Offs and Phage-Driven Restoration of Antibiotic Susceptibility.BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy · 2026
    Review
  9. Review
  10. Article
  11. Suppressing Transfer of Antibiotic Resistance by a Small RNA Virus.bioRxiv : the preprint server for biology · 2026
    Article
  12. Review
  13. Review
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anita TarasenkoFlinders Accelerator for Microbiome Exploration, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia.ORCID 0009-0003-4283-2374
Bhavya N PapudeshiFlinders Accelerator for Microbiome Exploration, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia.ORCID 0000-0001-5359-3100
Susanna R GrigsonFlinders Accelerator for Microbiome Exploration, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia.ORCID 0000-0003-4738-3451
Vijini MallawaarachchiFlinders Accelerator for Microbiome Exploration, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia.
Abbey L K HuttonFlinders Accelerator for Microbiome Exploration, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia.ORCID 0000-0002-2474-1327
Morgyn S WarnerMicrobiology & Infectious Diseases Directorate, SA Pathology, Central Adelaide Local Health Network, Adelaide, South Australia, Australia.
Jeremy J BarrSchool of Biological Sciences, Monash University, Melbourne, Victoria, Australia.ORCID 0000-0001-5603-5294
Jon IredellCentre for Infectious Diseases and Microbiology, The Westmead Institute for Medical Research, Westmead, New South Wales, Australia.
Bart EijkelkampCollege of Science and Engineering, Flinders University, Bedford Park, South Australia, Australia.ORCID 0000-0003-0179-8977
Robert A EdwardsFlinders Accelerator for Microbiome Exploration, College of Science and Engineering, Flinders University, Adelaide, South Australia, Australia.

Funding

Computational and Experimental Resources for Virome Analysis in Inflammatory Bowel Disease (CERVAID)RC2DK116713 · NIDDK · WASHINGTON UNIVERSITY · PI WANG, DAVID · 2019 to 2023
$8.9M
Australian Research Council DP220102915NIDDK NIH HHS RC2 DK116713
6 · The paper itself

Abstract

Multidrug-resistant (MDR) and extensively drug-resistant (XDR) ESKAPE pathogens pose a significant global health threat due to their ability to evade antibiotics through intrinsic and acquired mechanisms. These bacteria, including

Indexed as

Anti-Bacterial AgentsBacteriaBacterial InfectionsBacteriophagesDrug Resistance, Multiple, BacterialHumansPhage TherapyAnti-Bacterial Agentsefflux pump inhibitionESKAPEE pathogensmultidrug resistance (MDR)phage-antibiotic synergyphage therapy

Identifiers

PMID40920032
PMCPMC12506008

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.