Evidence map›Paper›PMID 40919938›Full record

ArticlemSystems2025

GEMsembler: consensus model assembly and structural comparison of genome-scale metabolic models across tools improve functional performance.

Elena K Matveishina, Bartosz J Bartmanski, Sara Benito-Vaquerizo, Maria Zimmermann-Kogadeeva

Abstract readComparative Study
In one paragraph

Article in mSystems, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Elena K MatveishinaGenome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.ORCID 0000-0003-4641-4906
Bartosz J BartmanskiGenome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.ORCID 0000-0002-0495-9150
Sara Benito-VaquerizoGenome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.ORCID 0000-0003-3936-9676
Maria Zimmermann-KogadeevaGenome Biology Unit, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany.ORCID 0000-0001-6021-1246

Funding

European Molecular Biology LaboratoryEuropean Research Council MetaboGutModel-101117769HORIZON EUROPE Framework Programme BlueRemediomics-101082304
6 · The paper itself

Abstract

Genome-scale metabolic models (GEMs) are widely used in systems biology to investigate metabolism and predict perturbation responses. Automatic GEM reconstruction tools generate GEMs with different properties and predictive capacities for the same organism. Since different models can excel at different tasks, combining them can increase metabolic network certainty and enhance model performance. Here, we introduce GEMsembler, a Python package designed to compare cross-tool GEMs, track the origin of model features, and build consensus models containing any subset of the input models. GEMsembler provides comprehensive analysis functionality, including identification and visualization of biosynthesis pathways, growth assessment, and an agreement-based curation workflow. GEMsembler-curated consensus models built from four

Indexed as

Genome, BacterialMetabolic Networks and PathwaysModels, BiologicalSoftwareSystems BiologyEscherichia coliEscherichia coligenetic algorithmLactobacillusmetabolic modeling

Identifiers

PMID40919938
PMCPMC12542698

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.