Evidence map›Paper›PMID 40919817›Full record

ArticlemBio2025

Prophage-encoded virulence factor, Gp05, contributes to endothelial cell dysfunction and immune evasion to promote persistent methicillin-resistant

Yi Li, Adhar C Manna, Sarah Ibrahim, Richard A Proctor, Ambrose L Cheung, Yan Q Xiong

Abstract read
In one paragraph

Article in mBio, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yi LiThe Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Adhar C MannaDepartment of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.ORCID 0000-0002-4055-2489
Sarah IbrahimThe Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.
Richard A ProctorUniversity of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Ambrose L CheungDepartment of Microbiology & Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire, USA.
Yan Q XiongThe Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, California, USA.ORCID 0000-0002-8732-6948

Funding

The role of purine biosynthesis and stringent response in persistent MRSA endovascular infectionsR01AI139244 · NIAID · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI XIONG, YAN Q. · 2019 to 2023
$2.2M
National Institute of Allergy and Infectious Diseases 1R01AI39244-01A1NIAID NIH HHS R01 AI139244
6 · The paper itself

Abstract

Methicillin-resistant IMPORTANCE: This study reveals the critical role of Gp05, a prophage-encoded protein, in promoting antibiotic persistence during MRSA endovascular infections by modulating endothelial cell responses. By demonstrating that Gp05 enhances

Indexed as

Endothelial CellsImmune EvasionMethicillin-Resistant Staphylococcus aureusProphagesStaphylococcal InfectionsViral ProteinsVirulence FactorsBacterial AdhesionCytokinesHumansCytokinesViral ProteinsVirulence Factorsendothelial cellendovascular infectionsimmune evasionMRSAphage-encoded virulence factor

Identifiers

PMID40919817
PMCPMC12506005

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.