ArticleEuropean journal of neurology2025
Identifying Poor Responders to STN DBS in Parkinson Disease: The Role of Rapid Disease Progression in the First Year in Optimal Responders to Levodopa.
Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Identifying Poor Responders to STN DBS in Parkinson Disease: The Role of Rapid Disease Progression in the First Year in Optimal Responders to Levodopa.European journal of neurology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe factors contributing to a poor response to subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) are not yet fully understood. Accordingly, predicting the outcome might be challenging particularly in those who display an optimal response to the Levodopa challenge test.
objectiveTo determine which factors may contribute to poor outcome of STN-DBS in PD.
methodsWe performed a retrospective analysis of consecutive PD patients treated with STN-DBS. Motor and non-motor variables were retrieved before surgery and at 1-year follow-up. Patients were divided into poor and good DBS responders by a cut-off value of less than 20% improvement of UPDRS-II in the OFF-medication ON-stimulation condition at 1 year.
resultsThirty-two (26.2%) of 122 patients were categorised as poor responders. Before surgery, poor responders had significantly less impairment in activity of daily living and less severe motor severity. Response to levodopa challenge test was similar between poor and good responders. Significant worsening of axial symptoms at 1-year follow-up in the off-medication off-stimulation condition was found in poor responders. On multivariable linear regression analysis, only the relative change of activity of daily living by dopaminergic medications before surgery predicted its improvement by neurostimulation at 1-year follow-up.
conclusionsCandidates for surgery with less impairment in activities of daily living may have less favourable outcomes after STN-DBS, despite an optimal response during the pre-operative Levodopa challenge. The worsening of axial symptoms due to disease progression might contribute to poorer outcomes, underscoring the need for better identification of these symptoms before surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.