Evidence map›Paper›PMID 40919659›Full record

ArticleClinical and experimental dental research2025

Nanostructured Clays Used as Carriers for Controlled Delivery of Antibacterial Compounds From Direct Restorative Dental Materials: A Scoping Review.

Bárbara Faria Sa de Barbosa, José Leôncio Ferreira Neto, Francisca Jennifer Duarte de Oliveira, Juliana Sales Osterno Leitão, Moan Jéfter Fernandes Costa, Pedro Henrique Sette-de-Souza, Pierre Basílio Almeida Fechine, Victor Pinheiro Feitosa, Boniek Castillo Dutra Borges

Abstract readScoping Review
In one paragraph

Article in Clinical and experimental dental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bárbara Faria Sa de BarbosaDepartment of Dentistry, Universidade Federal do Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil.
José Leôncio Ferreira NetoDepartment of Dentistry, Universidade Federal do Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil.
Francisca Jennifer Duarte de OliveiraDepartment of Dentistry, Universidade Federal do Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil.
Juliana Sales Osterno LeitãoGroup of Chemistry of Advanced Materials (GQMat), Department of Analytical Chemistry and Physical Chemistry, Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil.
Moan Jéfter Fernandes CostaCollege of Dentistry, Universidade de Pernambuco (UPE), Arcoverde, Pernambuco, Brazil.
Pedro Henrique Sette-de-SouzaCollege of Dentistry, Universidade de Pernambuco (UPE), Arcoverde, Pernambuco, Brazil.ORCID 0000-0001-9119-8435
Pierre Basílio Almeida FechineGroup of Chemistry of Advanced Materials (GQMat), Department of Analytical Chemistry and Physical Chemistry, Universidade Federal do Ceará (UFC), Fortaleza, Ceará, Brazil.
Victor Pinheiro FeitosaDepartment of Operative Dentistry, College of Dentistry, University of Iowa, Iowa City, Iowa, USA.ORCID 0000-0001-8795-9967
Boniek Castillo Dutra BorgesDepartment of Dentistry, Universidade Federal do Rio Grande do Norte (UFRN), Natal, Rio Grande do Norte, Brazil.ORCID 0000-0003-4313-5776

Funding

The authors received no specific funding for this work.
6 · The paper itself

Abstract

objectiveThrough a scoping review, this study meticulously mapped and characterized these nanostructured clays used to release antibacterial active compounds from direct restorative dental materials. MATERIAL AND

methodsThe systematic approach involved searches in the PubMed/MEDLINE, Lilacs, Web of Science, Scopus, ScienceDirect, and Embase databases. Two independent and calibrated researchers (kappa: 0.94) performed all systematic steps according to the PRISMA guideline and the Joanna Briggs Institute Scoping Review Methodology Group (JBI) protocol. The reviewers developed a data extraction table to gather key information.

resultsA total of 782 articles were retrieved in the initial search using the specified strategies. After thoroughly reviewing the manuscripts, five were selected following the exclusion of duplicates and application of eligibility criteria. Montmorillonite and halloysite nanotubes emerged as the predominant nanostructured clay. Cetylpyridinium chloride was the most common active agent, notable for its antibacterial properties. Resin-based composites were the most frequently studied direct restorative material for the prevention of recurrent caries.

conclusionAlthough the number of primary studies published in the literature was limited, montmorillonite and halloysite nanotubes appear to be promising nanocarriers for antibacterial active compounds in direct restorative dental materials.

Indexed as

Anti-Bacterial AgentsClayDental MaterialsDrug CarriersNanostructuresBentoniteCetylpyridiniumComposite ResinsDelayed-Action PreparationsDental CariesDental Restoration, PermanentHumansNanotubesAnti-Bacterial AgentsBentoniteCetylpyridiniumClayComposite ResinsDelayed-Action PreparationsDental MaterialsDrug Carriersdental materialsdentistrymontmorillonitenanoparticle drug delivery system

Identifiers

PMID40919659
PMCPMC12415706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.