Evidence map›Paper›PMID 40919652›Full record

ArticleClinical and experimental dental research2025

Biosynthesized Silver Nanoparticles Modulate Inflammation in a Palatine Wound Model.

Morgana Francisco Machado Guzzatti, Airam Barbosa de Moura, Ligia Milanez Venturini, Laura de Roch Casagrande, Igor Ramos Lima, Camila da Costa, Ellen de Pieri, Lariani Tamires Witt Tietbohl, Paulo Emilio Feuser, Ricardo Andrez Machado-de-Ávila and 3 more

Abstract read
In one paragraph

Article in Clinical and experimental dental research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Mechanistic insights intoJournal of advanced veterinary and animal research · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Morgana Francisco Machado GuzzattiLaboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina state, Brazil.
Airam Barbosa de MouraLaboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina state, Brazil.
Ligia Milanez VenturiniLaboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina state, Brazil.
Laura de Roch CasagrandeLaboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina state, Brazil.
Igor Ramos LimaLaboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina state, Brazil.
Camila da CostaLaboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina state, Brazil.
Ellen de PieriLaboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina state, Brazil.
Lariani Tamires Witt TietbohlLaboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina state, Brazil.
Paulo Emilio FeuserLaboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina state, Brazil.
Ricardo Andrez Machado-de-ÁvilaLaboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina state, Brazil.
Yaodong GuDepartment of Rehabilitation Medicine, Ningbo No. 2 Hospital, Ningbo, Zhejiang, China.
Anand ThirupathiLaboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina state, Brazil.
Paulo Cesar Lock SilveiraLaboratory of Experimental Physiopathology, Program of postgraduate in Science of Health, Universidade do Extremo Sul Catarinense, Criciúma, Santa Catarina state, Brazil.ORCID 0000-0003-4908-2257

Funding

This study was supported by grants from the National Council for Scientific and Technological Development (CNPq), the Santa Catarina State Research and Innovation Support Foundation (FAPESC), the Coordination for the Improvement of Higher Education Personnel (CAPES), and the University of the Extreme South of Santa Catarina (UNESC). The authors also acknowledge funding from the Research Academy of Medicine Combining Sports, Ningbo (No. 2023001), the Project of Ningbo Leading Medical & Health Discipline (No. 2022-F15, No. 2022-F22), Ningbo Natural Science Foundation (2022J065, 2022J120), Ningbo Clinical Research center for Orthopedics and Exercise Rehabilitation (2024L004), and Zhejiang Rehabilitation Medical Association Scientific Research Special Fund (ZKKY2023001), for the completion of this study.
6 · The paper itself

Abstract

objectivesThis study aimed to compare the effects of silver nanoparticles (AgNPs) synthesized with Curcumin (Curcuma longa L.) or Açai (Euterpe oleracea) versus a commercial treatment and photobiomodulation in rat palatal wounds.

methodsIn vitro cell viability tests assessed nanoparticle toxicity. The animals were initially anesthetized, and circular lesions were created in the palatine mucosa using a 4 mm/diameter punch. The first treatment session commenced 24 h after the injury and continued daily for 5 days. Twenty-four hours after the final treatment, the animals were euthanized, and the palatal mucosa tissue was collected for histological and biochemical analyses.

resultsAgNPs-Cur significantly reduced pro-inflammatory cytokines and oxidant markers, increased anti-inflammatory cytokines, the wound contraction rate, and the collagen area, and reduced the inflammatory infiltrate compared to the controls.

conclusionThe therapies effectively aided inflammation resolution and accelerated tissue repair. This study highlights potential cost-effective and efficient alternatives for oral and palatal mucosa wound healing, improving upon standard commercial treatments.

Indexed as

InflammationMetal NanoparticlesMouth MucosaPalateSilverWound HealingAnimalsAnti-Inflammatory AgentsCell SurvivalCurcuminCytokinesDisease Models, AnimalMaleRatsAnti-Inflammatory AgentsCurcuminCytokinesSilvergreen synthesisinflammationoxidative stresspalatal woundssilver nanoparticles

Identifiers

PMID40919652
PMCPMC12415710

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.