Evidence map›Paper›PMID 40919618›Full record

ArticleACS applied materials & interfaces2025

Magnetic Platinum-Cobalt Nanoparticles as Peroxidase Mimics for Detection of Cancer Biomarkers.

Xiaohan Sun, Shikuan Shao, Lifang Hu, Moon J Kim, Xiaohu Xia

Abstract read
In one paragraph

Article in ACS applied materials & interfaces, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Can nanozymes achieve more than enzymes?Nature reviews. Materials · 2026
    Article
  2. Peroxidase-Mimicking Nanozymes for Rapid Detection of Infectious Diseases.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Xiaohan SunDepartment of Chemistry, University of Central Florida, Orlando, Florida 32816, United States.ORCID 0009-0005-6392-7369
Shikuan ShaoDepartment of Chemistry, University of Central Florida, Orlando, Florida 32816, United States.ORCID 0000-0003-0149-9942
Lifang HuDepartment of Materials Science and Engineering, University of Texas at Dallas, Richardson, Texas 75080, United States.
Moon J KimDepartment of Materials Science and Engineering, University of Texas at Dallas, Richardson, Texas 75080, United States.ORCID 0000-0002-2972-493X
Xiaohu XiaDepartment of Chemistry, University of Central Florida, Orlando, Florida 32816, United States.ORCID 0000-0002-6372-7712

Funding

Improving ELISA Technology using Ultra-efficient Peroxidase MimicsR01EB035519 · NIBIB · UNIVERSITY OF CENTRAL FLORIDA · PI Xiaohu Xia · 2024 to 2026
$825k
NIBIB NIH HHS R01 EB035519
6 · The paper itself

Abstract

Inorganic nanomaterial-based peroxidase mimics have recently emerged as promising alternatives to natural peroxidases for enhancing the detection sensitivity of bioassays, such as enzyme-linked immunosorbent assay (ELISA). Among them, magnetically active peroxidase mimics are particularly advantageous due to their ability to facilitate efficient separation and enrichment of target analytes. However, most reported magnetic peroxidase mimics suffer from limited catalytic efficiency and stability. In this study, we introduce platinum-cobalt nanoparticles (Pt-Co NPs) as an innovative class of magnetically active peroxidase mimics. These Pt-Co NPs exhibit significantly enhanced catalytic activity and outstanding stability over a wide pH range and at elevated temperatures, outperforming conventional Fe

Indexed as

Biomarkers, TumorBiomimetic MaterialsCobaltMagnetite NanoparticlesMetal NanoparticlesPeroxidasePlatinumCatalysisEnzyme-Linked Immunosorbent AssayHumansLimit of DetectionNeoplasmsBiomarkers, TumorCobaltMagnetite NanoparticlesPeroxidasePlatinumbioassaycatalysisdetectionnanoparticleperoxidase

Identifiers

PMID40919618
PMCPMC12812028

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.