ArticleDiabetes, metabolic syndrome and obesity : targets and therapy2025
Effects of Brown Rice, Meal Replacements, and Anti-Obesity Drugs on Mitochondria in Obese Rats.
Article in Diabetes, metabolic syndrome and obesity : targets and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Mitochondrial medicine in obesity: a scoping review.Open medicine (Warsaw, Poland) · 2026Review
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Obesity remains a critical global health challenge, intricately linked to poor dietary quality, gut microbiota dysbiosis, and mitochondrial dysfunction. Purpose: This study aimed to investigate the comparative effects of brown rice, meal replacements, and thiazolidinediones on mitochondrial abundance and gut microbiota composition in a rat model of diet-induced obesity. Methods and Materials: A total of twenty male Sprague Dawley rats were randomly assigned to five groups: control, high-fat high-fructose diet, and three intervention groups receiving the same obesogenic diet supplemented with brown rice, meal replacement, or thiazolidinediones for twelve weeks. Mitochondrial activity in white adipose tissue was quantified using fluorescent staining techniques, while gut microbiota composition was assessed by analyzing the Firmicutes-to-Bacteroidetes ratio through quantitative PCR. Results: Significant differences were observed in fiber intake and gut microbiota composition across groups (p < 0.001). The brown rice (BR) group exhibited the highest fiber intake (6.36 ± 1.01 g/day) and a favorable Firmicutes/Bacteroidetes ratio (1.36 ± 0.09). Mitochondrial count was significantly higher in the meal replacement (MR) group (60 ± 4.08) compared to the HFHF group (30 ± 2.89; p < 0.001). These findings suggest that high-fiber dietary interventions may enhance mitochondrial biogenesis and improve gut microbial balance, providing metabolic benefits in diet-induced obese models. Conclusion: These findings demonstrate that dietary fiber-rich interventions can modulate host metabolism through concurrent improvement of gut microbiota and mitochondrial function. Brown rice and meal replacements offer promising, non-pharmacological strategies for obesity management, while pharmacological agents such as thiazolidinediones may provide additive benefits through targeted mitochondrial enhancement. This study supports an integrated approach to metabolic health and underscores the significance of diet quality in the prevention and treatment of obesity.
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