ArticlePalliative medicine reports2025
Code Status Transitions of Patients with Aneurysmal Subarachnoid Hemorrhage in the Intensive Care Unit.
Article in Palliative medicine reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Corrections and comments
- Erratum issued
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Aneurysmal subarachnoid hemorrhage (aSAH) carries high mortality rates and often requires critical family decisions about code status when complications occur. The American Heart Association provides treatment guidelines but acknowledges a significant knowledge gap regarding do-not-resuscitate or do-not-intubate (DNR/DNI) decisions in patients with aSAH, challenging clinicians in identifying appropriate timing for these discussions. Aim: To identify demographic and clinical physiological factors associated with code status transition in adults with aSAH admitted to the intensive care unit, supporting value-based decision making through more informed and timely discussions between health care providers and families that align with patients' core values and preferences. Methods: Retrospective cohort study analyzing Medical Information Mart for Intensive Care IV database (2008-2022) data from 731 patients with aSAH. Researchers collected demographics, vital signs, laboratory tests, disease severity scores, and code status transition, performing univariate and multivariate Cox regression analyses to identify significant predictors. Results: Among patients initially with full-code status, 25.8% transitioned to DNR/DNI during hospitalization. Multivariate analysis identified four independent predictors: advanced age (hazard ratio [HR] = 1.024), lower mean blood pressure (HR = 0.987), higher simplified acute physiology score II (SAPS II) score (HR = 1.018, each one-point increase raises transition risk by 1.8%), and hospice services (HR = 6.951). Patients with code status limitations received less invasive therapy, more hospice services, and had higher mortality rates. Conclusion: Age, blood pressure, SAPS II, and hospice services predict code status transitions in patients with aSAH. Identifying high-risk patients enables timely code status discussions, ensuring treatment aligns with patient values and improving family decision making during critical situations.
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