ArticleTransplantation direct2025
ECP-induced Apoptosis: How Noninflammatory Cell Death Counterbalances Ischemia/Reperfusion Injury.
Article in Transplantation direct, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed.
- Exploring the Role of Extracorporeal Photopheresis in Kidney Transplant Management.Transplantation direct · 2025Article
- Potential Biomarkers of Therapeutic Response to ECP in Solid Organ Transplantation.Transplantation direct · 2025Article
- exTra Mini-review Series on ECP in Transplantation.Transplantation direct · 2025Article
- Extracorporeal Photopheresis in Lung Transplantation: Present Applications and Emerging Research.Transplantation direct · 2025Article
- Potential Impact of Extracorporeal Photopheresis on Trained Immunity and Organ Transplant Acceptance.Transplantation direct · 2025Article
- Extracorporeal Photopheresis: Does It Have a Potential Place Among Cell-based Therapies?Transplantation direct · 2025Article
- Extracorporeal Photopheresis Stimulates Tissue Repair after Transplantation.Transplantation direct · 2025Article
- Extracorporeal Photopheresis: Secreted Factors That Promote Immunomodulation.Transplantation direct · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracorporeal photopheresis (ECP) is a therapeutic procedure that is increasingly recognized for its efficacy in treating immune-mediated diseases, including transplant rejection. Its main mechanism is ex vivo apoptosis induction in leukocytes from patients by incubation with 8-methoxypsoralen and irradiation with ultraviolet A light. The process involves DNA cross-linking, which leads to a cascade of events within the cell and ultimately to apoptosis induction. Although ECP has been used for almost 40 y, there remain many questions about its immunological mechanisms and therapeutic potential. Here, we review current knowledge about mechanisms of apoptosis induction in subsets of peripheral blood mononuclear cells and interactions of apoptotic leukocytes with immune cells. We also highlight the challenges of reproducibly inducing cell death in a clinical manufacturing procedure and propose innovative ways to improve and quality-control ECP photopheresates.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.