Evidence map›Paper›PMID 40919418›Full record

ArticleJournal of Alzheimer's disease reports

Adverse reproductive outcomes and future risk of incident dementia: The modifying effect of genetic susceptibility.

Qiaoqiao Xu, Chengzhe Tao, Sijia Dai, Zhixi Lu, Michael Aschner, Guangfeng Long, Shaojun Li, Cheng Xu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of Alzheimer's disease reports. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qiaoqiao XuState Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Chengzhe TaoState Key Laboratory of Reproductive Medicine and Offspring Health, School of Public Health, Nanjing Medical University, Nanjing, China.
Sijia DaiDepartment of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.
Zhixi LuKey Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, China.
Michael AschnerDepartment of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY, USA.
Guangfeng LongDepartment of Clinical Laboratory, Children's Hospital of Nanjing Medical University, Nanjing, China.
Shaojun LiDepartment of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.
Cheng XuDepartment of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China.ORCID https://orcid.org/0000-0003-2605-2100

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Adverse reproductive outcomes (AROs) in women can lead to the occurrence of a variety of diseases later in life. However, research on AROs and dementia risk in women has not been reported. Objective: This study explored the effects of miscarriage and stillbirth on future dementia risk in women. Methods: The Cox proportional hazards model was used to clarify the association between miscarriage, stillbirth, and dementia risk. In this cohort, only women with a history of miscarriage and stillbirth were selected. A genetic risk score for dementia was constructed, and the combined effect of miscarriage, stillbirth, and the genetic risk score for dementia on the future risk of incident dementia was determined. Results: For each increase in the number of miscarriages and stillbirths, the risk of dementia increased by 5% and 22%, respectively. Compared to women who had a low genetic risk score, no miscarriages and at least one live-born infant, women with more than 3 miscarriages and a high genetic risk score had a significantly increased risk of dementia. Conclusions: Our results indicate that miscarriage and stillbirth are associated with an increased risk of dementia, especially in women with a high genetic risk score.

Indexed as

Alzheimer's diseasedementiagenetic susceptibilitymiscarriagestillbirthUK biobank

Identifiers

PMID40919418
PMCPMC12411706

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.