Evidence map›Paper›PMID 40919278›Full record

ReviewMagnetic resonance letters2023

Amide proton transfer imaging of Alzheimer's disease and Parkinson's disease.

Chunmei Li, Jinyuan Zhou, Di Wang, Xinyang Li, Shanshan Jiang, Yi Zhang, Zhibo Wen, Guangbin Wang, Fuhua Yan, Min Chen

Abstract readReview
In one paragraph

Review in Magnetic resonance letters, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Chunmei LiDepartment of Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Jinyuan ZhouDepartment of Radiology, Johns Hopkins University, Baltimore, MD, 21287, USA.
Di WangDepartment of Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Xinyang LiDepartment of Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China.
Shanshan JiangDepartment of Radiology, Johns Hopkins University, Baltimore, MD, 21287, USA.
Yi ZhangKey Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, 310027, China.
Zhibo WenDepartment of Radiology, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, China.
Guangbin WangDepartment of Radiology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, 250021, China.
Fuhua YanDepartment of Radiology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200025, China.
Min ChenDepartment of Radiology, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing, 100730, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Amide proton transfer (APT) magnetic resonance imaging (MRI) is an important molecular imaging technique at the protein level in tissue. Neurodegenerative diseases have a high likelihood of causing abnormal protein accumulation in the brain, which can be detected by APT MRI. This article briefly introduces the principles and image processing technology of APT MRI, and reviews the current state of research on Alzheimer's disease and Parkinson's disease using this technique. Early applications of this approach in these two neurodegenerative diseases are encouraging, which also suggests continued technical development and larger clinical trials to gauge the value of this technique.

Indexed as

Alzheimer's diseaseAmide proton transfer imagingMRIParkinson's disease

Identifiers

PMID40919278
PMCPMC12406532

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.