ArticleReports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology2025
Evaluation of the liver load index as a predictor of liver exposure in right breast radiotherapy.
Article in Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: To compare doses deposited to the liver during right breast radiotherapy with static and dynamic radiotherapy techniques. The second aim was to introduce the liver load index (LLI), a novel index developed to estimate radiation exposure to the liver prior to treatment selection. Materials and methods: We prepared radiotherapy treatment plans for ten patients with right breast cancer. Plans were created for conventional 3D conformal radiation therapy (3D-CRT), intensity-modulated radiation therapy (IMRT) with and without dose optimisation to liver, and hybrid 3D-CRT/volumetric modulated arc therapy (VMAT). Dosimetric evaluation was based on dose-volume histogram (DVH) parameters. The Wilcoxon test was used to assess differences between treatment plans. Spearman's rank correlation was used to determine the correlation between the LLI and the radiation dose to the liver. Result: IMRT plans resulted in significantly higher D Conclusion: The LLI provides an accurate estimation of liver exposure to radiation during right breast radiotherapy. This index, which is calculated prior to treatment planning, is highly accurate, as evidenced by the strong correlation between the LLI and the mean liver dose.
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