Evidence map›Paper›PMID 40919199›Full record

ArticleFrontiers in microbiology2025

HoloMoA: a holography and deep learning tool for the identification of antimicrobial mechanisms of action and the detection of novel MoA.

Zohreh Sedaghat, Benoît Courbon, Héloïse Botrel, Hélène Dugua, Pawel Tulinski, Laethitia Alibaud, Lucia Pagani, Derry Mercer, Cyril Guyard, Christophe Védrine and 1 more

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Zohreh Sedaghat *BIOASTER, Lyon, France.
Benoît Courbon *BIOASTER, Lyon, France.
Héloïse BotrelBIOASTER, Lyon, France.
Hélène DuguaBIOASTER, Lyon, France.
Pawel TulinskiBIOASTER, Lyon, France.
Laethitia AlibaudBIOASTER, Lyon, France.
Lucia PaganiBIOASTER, Lyon, France.
Derry MercerBIOASTER, Lyon, France.
Cyril GuyardBIOASTER, Lyon, France.
Christophe VédrineBIOASTER, Paris, France.
Sophie DixneufBIOASTER, Lyon, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We propose an innovative technology to classify the Mechanism of Action (MoA) of antimicrobials and predict their novelty, called HoloMoA. Our rapid, robust, affordable and versatile tool is based on the combination of time-lapse Digital Inline Holographic Microscopy (DIHM) and Deep Learning (DL). In combination with hologram reconstruction. DIHM enables a label-free, time-resolved visualization of bacterial cell morphology and quantitative phase map to reveal phenotypic responses to antimicrobials, while DL techniques are powerful tools to extract discriminative features from image sequences and classify them. We assessed the performance of HoloMoA on

Indexed as

antimicrobial agentsdeep learningdrug discoveryEscherichia coliholographic microscopymechanisms of action

Identifiers

PMID40919199
PMCPMC12411554

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.