Evidence map›Paper›PMID 40919151›Full record

ArticleFrontiers in oncology2025

The global, regional, and national impact of laryngeal cancer from 1990 to 2021, along with forecasts for 2050: a comprehensive analysis for the Global Burden of Disease 2021 research.

Tingting Duan, Yuxia Zou, Xuan Liu, Yue Du, Ruihu Li, Jingxiang Cai, Jumei Li, Xiaofeng Wang, Xuejun Zhou, Shun Ding

Abstract read
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In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tingting Duan *Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Hainan Medical University, Haikou, China.
Yuxia Zou *Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Hainan Medical University, Haikou, China.
Xuan Liu *Department of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Hainan Medical University, Haikou, China.
Yue DuDepartment of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Hainan Medical University, Haikou, China.
Ruihu LiDepartment of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Hainan Medical University, Haikou, China.
Jingxiang CaiDepartment of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Hainan Medical University, Haikou, China.
Jumei LiDepartment of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Hainan Medical University, Haikou, China.
Xiaofeng WangDepartment of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Hainan Medical University, Haikou, China.
Xuejun ZhouDepartment of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Hainan Medical University, Haikou, China.
Shun DingDepartment of Otolaryngology, Head and Neck Surgery, The First Affiliated Hospital, Hainan Medical University, Haikou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Laryngeal cancer (LC), the second most common head and neck malignancy, with significant global geographical disparities in incidence and mortality, was analyzed using 2021 Global Burden of Disease (GBD) data to assess Socio-Demographic Index (SDI) correlations and project disease burden through 2050, aiming to reduce its global impact. Methods: Using data from the GBD 2021, we investigated the incidence, prevalence, deaths, and Disability-Adjusted Life Years (DALYs) of LC, as well as trends, age-sex-time patterns, driving factors, and projections up to 2050. Results: In 2021, LC increased with age and decreased after the age of 70. The incidence and mortality rates of male patients are much higher than those of female patients, and the gap between men and women gradually narrows after the age of 70. From 1990 to 2021, the overall disease burden of LC globally showed a downward trend and is expected to further decline by 2050. However, there are significant differences among different countries and regions. In high SDI regions, the disease burden gradually decreases after reaching its peak, while in low SDI regions, the reduction or increase in the disease burden is relatively small. Population growth and aging are the main factors leading to the increase in the LC burden, but epidemiological changes have alleviated this burden to a certain extent. Smoking and excessive alcohol consumption are the main risk factors for LC. Conclusions: While the global LC burden has moderated, significant disparities persist across SDI regions. Healthcare quality improvements and targeted prevention, with this analysis offering evidence-based guidance for public health strategy formulation.

Indexed as

deathsdisability-adjusted life yearsdisease burdenincidencelaryngeal cancerprevalence

Identifiers

PMID40919151
PMCPMC12411215

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.