ArticleFrontiers in oncology2025
Development and evaluation of a nomogram prediction model for invasion and metastasis in primary liver cancer based on serum CD147 and IL-6.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aims to develop a prediction model for invasive metastasis of primary liver cancer based on serum extracellular matrix metalloproteinase-inducing factor (CD147) and interleukin-6 (IL-6). Methods: Between July 2022 and August 2024, 170 surgically treated primary hepatocellular carcinoma patients at our hospital were recruited. They were divided into a training group ( Results: In the training group, compared with the noninvasive metastasis group, patients in the invasive metastasis group had a significantly lower percentage of intact envelope and tumor size ≥5 cm, and significantly higher serum alpha-fetoprotein (AFP), alkaline phosphatase (ALP), C-reactive protein/albumin ratio (CAR), oncoglobulin (CEA), CD147, and IL-6 levels (all Conclusion: The prediction model based on serum CD147, IL-6, and other risk factors for the invasion and metastasis of primary hepatocellular carcinoma demonstrates high diagnostic value.
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