Raw lacquer-associated familial chronic myelomonocytic leukemia with multi-hit

Yang Zhang, Yujiao Luo, Hongling Peng, Yafei Yin, Guangsen Zhang

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Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Yang ZhangDepartment of Oncology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Yujiao LuoDepartment of Hematology, Institute of Molecular Hematology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Hongling PengDepartment of Hematology, Institute of Molecular Hematology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Yafei YinDepartment of Hematology, The Affiliated Changsha Central Hospital, Hengyang Medical School, University of South China, Changsha, Hunan, China.

Guangsen ZhangDepartment of Hematology, Institute of Molecular Hematology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China.

Funding

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6 · The paper itself

Abstract

Background: To explore the potential association between long-term exposure to raw lacquer and the development of chronic myelomonocytic leukemia (CMML). Methods: We analyzed the clinical and hematological characteristics of an elderly couple with CMML. Whole-exome sequencing (WES) was performed to identify relevant gene variants, with a focus on Results: Two unrelated CMML patients within the same family, both with over 40 years of raw lacquer exposure, developed CMML. WES revealed that both patients harbored multi-hit Conclusions: Long-term exposure to raw lacquer may be associated with the onset of familial CMML. CMML patients with multi-hit

Indexed as

chronic myelomonocytic leukemiafamilialN-rasraw lacquerRunx1TET2 mutation

Identifiers

PMID40919141

DOI10.3389/fonc.2025.1605369

PMCPMC12411432

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