ArticleJournal of hepatocellular carcinoma2025
Prognostic Role of Short-Chain Fatty Acid-Producing Gut Microbiota and Gut Microbial Dynamics in Patients with Hepatocellular Carcinoma Receiving Chemoembolization: A Prospective Study.
Article in Journal of hepatocellular carcinoma, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Transarterial chemoembolization (TACE) may cause gut dysbiosis by increasing portal vein pressure. However, its association with clinical outcomes remains unknown. We hypothesized that gut microbiota composition and diversity are associated with treatment response and prognosis in patients with hepatocellular carcinoma (HCC) undergoing TACE. Patients and Methods: This single-center, prospective cohort study included 96 adult HCC patients treated with TACE from April 2021 to November 2023. Fecal samples were collected before TACE (P0), one day (P1), and one month (P2) after TACE. Fecal 16S rRNA taxonomy was analyzed to evaluate microbial diversity, composition, and dynamic changes at each time point. The primary outcome was the association between the initial response to TACE and changes in microbial diversity and composition. Results: Out of the total participants, 63 (65.6%) were responders and 33 (34.4%) were non-responders. Responder stool samples had higher alpha-diversity than those of non-responders at baseline (median Shannon index: 4.26 vs 4.09), albeit not reaching statistical significance, and a higher abundance of short-chain fatty acid (SCFA)-producing bacteria at all time points. Alpha-diversity significantly decreased one day after TACE ( Conclusion: Specific SCFA-producing bacteria, such as
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