Evidence map›Paper›PMID 40918986›Full record

ArticleFrontiers in nuclear medicine2025

Quantification of neuroinflammation in spinal cord and neuroforamina of patients with painful cervical radiculopathy using [

Ivo J Lutke Schipholt, Gwendolyne G M Scholten-Peeters, Meghan A Koop, Michel W Coppieters, Ronald Boellaard, Elsmarieke van de Giessen, Bastiaan C Ter Meulen, Marieke Coenen, Carmen Vleggeert-Lankamp, Paul R Depaauw and 3 more

Abstract read
In one paragraph

Article in Frontiers in nuclear medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Ivo J Lutke SchipholtDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences - Program Musculoskeletal Health, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Gwendolyne G M Scholten-PeetersDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences - Program Musculoskeletal Health, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Meghan A KoopDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences - Program Musculoskeletal Health, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Michel W CoppietersDepartment of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Amsterdam Movement Sciences - Program Musculoskeletal Health, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.
Ronald BoellaardDepartment of Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam University Medical Centre, Location VUmc, Amsterdam, Netherlands.
Elsmarieke van de GiessenDepartment of Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam University Medical Centre, Location VUmc, Amsterdam, Netherlands.
Bastiaan C Ter MeulenDepartment of Neurology, OLVG Amsterdam, Amsterdam, Netherlands.
Marieke CoenenDepartment of Human Genetics, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, Netherlands.
Carmen Vleggeert-LankampDepartment of Neurosurgery, Leiden University Medical Center, Leiden, Netherlands.
Paul R DepaauwDepartment of Neurosurgery, Elisabeth-TweeSteden Ziekenhuis, Tilburg, Netherlands.
Bart N M van BerckelSchool of Health Sciences and Social Work, Griffith University, Brisbane/Gold Coast, QLD, Australia.
Adriaan A LammerstmaDepartment of Radiology and Nuclear Medicine, Vrije Universiteit Amsterdam, Amsterdam University Medical Centre, Location VUmc, Amsterdam, Netherlands.
Maqsood YaqubSchool of Health Sciences and Social Work, Griffith University, Brisbane/Gold Coast, QLD, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Animal models of nerve compression have revealed neuroinflammation not only at the entrapment site, but also remotely at the spinal cord. However, there is limited information on the presence of neuroinflammation in human compression neuropathies. The objectives of this study were to: (1) assess which tracer kinetic model most optimally quantified [ Results: The single tissue (1T2k) compartment model was the preferred model to describe [ Conclusions: These results indicate that a 1T2k model with metabolite corrected image derived input function can be used to describe the kinetics of [

Indexed as

cervical radiculopathyimmunoactivationneuroinflammationneuropathic painPET imagingPET quantification data collection

Identifiers

PMID40918986
PMCPMC12408627

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.