Trial reportDrug design, development and therapy2025
Effect of Epidural Catheter Design on Analgesic Efficacy During Programmed Intermittent Epidural Boluses: A Randomized Double-Blinded Controlled Trial.
Trial report in Drug design, development and therapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Purpose: To compare analgesic outcomes between single- and multi-orifice epidural catheters at a 360-mL/h delivery rate during programmed intermittent epidural bolus. Patients and Methods: In this prospective randomized double-blinded controlled trial, 102 healthy nulliparous parturients requesting labor analgesia at the Shanghai First Maternity and Infant Hospital were enrolled from July to September 2023. Participants were given either single- or multi-orifice catheters for epidural analgesia (0.1% ropivacaine with 0.3 µg/mL of sufentanil; 10 mL every 45 min at 360 mL/h). The primary outcome was ropivacaine consumption per hour, calculated as the total amount of ropivacaine administered divided by the duration of labor analgesia (mg/h). Results: Median ropivacaine consumption per hour was not significantly different: 12.6 mg/h [11.6-13.2 mg/h] for single-orifice vs 12.8 mg/h [12.3-13.3 mg/h] for multi-orifice catheters (difference 29%; 95% confidence interval [CI], -10.2 to 68.2%; Conclusion: Single-orifice catheters did not enhance analgesia quality during labor maintenance under a 360-mL/h programmed intermittent epidural bolus delivery rate but were linked to more rapid analgesic onset than multi-orifice catheters.
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