ReviewInternational journal of nanomedicine2025
Phytochemicals in Bone Therapy: Exploring Natural Alternatives for Bone Health.
Review in International journal of nanomedicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Bioregulatory periodontal medicine: could the molecular networks, inflammation and system biology modify the auto-regulatory capacity of the patients?Frontiers in physiology · 2026Pooled it
- Surface-Engineered Phytochemical Nanomedicines for Postmenopausal Osteoporosis: Skeletal Targeting, Imaging-Supported Evaluation, and Therapeutic Performance.Pharmaceutics · 2026Review
- Bioactive Natural Compounds: A Review of Their Integration into Bone Tissue Engineering Scaffolds.Annals of biomedical engineering · 2026Review
- 3D-printed dictamni-calcium silicate scaffolds modulate the osteoimmune microenvironment and enhance macrophage-derived exosomal miR-21 signaling in vascularized bone regeneration.Journal of nanobiotechnology · 2026Article
- Therapeutic potential of natural products from Traditional Chinese Medicine in the treatment of osteoporosis.Frontiers in pharmacology · 2026Review
- Plant-derived food bioactives in bone health: from multi-targeted roles to molecular mechanisms in osteoporosis.Frontiers in nutrition · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone diseases such as osteoporosis and osteoarthritis are increasingly prevalent, particularly in aging populations. While conventional treatments, including synthetic drugs and mineral supplements, are effective yet often associated with side effects and long-term economic burdens. Active compounds derived from nature, "Phytochemicals" have garnered attention due to their potential to provide safer and more sustainable alternative therapeutic options. However, due to their complex structure and poor pharmacokinetics, their clinical applications are limited. Nano-drug delivery systems address these limitations by developing phytochemical-based nanocarriers, which enable targeted delivery, protect active compounds, and enhance both pharmacokinetics and pharmacodynamics. Given the limitations of synthetic treatments, there is growing interest in exploring phytochemicals and plants and herbal extracts to support bone health. This review focuses on nano-phytochemical approaches for bone therapy, outlining key phytochemicals, their natural sources, nanoformulations, and mechanisms of action. It also evaluates current commercial supplements and highlights the challenges and future directions for clinical translation of nano-phytomedicine in bone health management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.