Evidence map›Paper›PMID 40918914›Full record

ArticleCureus2025

Chronic HIV Infection Associated With Motor Neuron Disease and Parkinsonism: A Case Report and Narrative Review.

Pedro V Sabbadini, Marco A Orsini, João Carlos Amorelli Figueira, Omar H Ashmawi, Amanda Amorelli Fernandes, Joao V Costa, Thiago De Mello Tavares, Marcos De Freitas, Acary S Oliveira, Billy McBenedict

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pedro V SabbadiniNeurology, Fluminense Federal University, Niterói, BRA.
Marco A OrsiniNeurology, Federal University of Rio de Janeiro, Rio de Janeiro, BRA.
João Carlos Amorelli FigueiraNeurology, Fluminense Federal University, Niterói, BRA.
Omar H AshmawiNeurology, Fluminense Federal University, Niterói, BRA.
Amanda Amorelli FernandesGeneral Surgery, Petrópolis School of Medicine, Petrópolis, BRA.
Joao V CostaNeurology, Fluminense Federal University, Niterói, BRA.
Thiago De Mello TavaresFamily Medicine, Federal University of Santa Catarina, Florianópolis, BRA.
Marcos De FreitasNeurology, Federal University of Rio de Janeiro, Rio de Janeiro, BRA.
Acary S OliveiraNeurology, Federal University of São Paulo, São Paulo, BRA.
Billy McBenedictNeurosurgery, Fluminense Federal University, Niterói, BRA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Motor neuron disease and parkinsonism syndromes associated with chronic HIV infection are extremely rare, with only a few cases reported in major medical databases. We report a case from Brazil involving a patient with a chronic, well-controlled HIV infection for approximately 15 years, demonstrating a good response to highly active antiretroviral therapy. Despite the absence of viral replication, the patient developed atypical clinical and topographical features consistent with both pyramidal and extrapyramidal syndromes. This raises the question of whether such findings could be linked to chronic HIV infection, occurring simultaneously even in the absence of active viral replication, particularly given that other potential diagnoses were excluded.

Indexed as

chronic hivextrapyramidal syndromesmotor neuron disease (mnd)neurodegenerationparkinsonismpyramidal syndromes

Identifiers

PMID40918914
PMCPMC12413669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.