ArticleCureus2025
Beginning of the End (BOTE) Sign in the Setting of Recurrent Molluscum Contagiosum in a Child.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Molluscum contagiosum (MC) is a common cutaneous viral infection predominantly affecting children. In this report, we present the case of a five-year-old male with recurrent MC who developed the beginning of the end (BOTE) sign, reflecting an inflammatory response that correlates with imminent lesion resolution. The patient's lesions were monitored without further intervention following the appearance of the BOTE sign, and complete resolution was documented in roughly two months. Serial photographs taken by the patient's parent provided visual documentation of the natural disease progression and healing of the lesions. Our case underscores the importance of distinguishing the BOTE sign from secondary bacterial infection and highlights its value in predicting spontaneous resolution, allowing clinicians to confidently opt for conservative management.
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