Evidence map›Paper›PMID 40918903›Full record

ArticleCureus2025

Sebaceous Carcinoma of the Breast: A Case Report and Review of the Literature.

Fadwa Haboub, Othmane Zouiten, Mohamed El Fadli, Leila Afani, Rhizlane Belbaraka

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fadwa HaboubMedical Oncology, Mohammed VI University Hospital of Marrakech, Marrakech, MAR.
Othmane ZouitenMedical Oncology, Mohammed VI University Hospital of Marrakech, Marrakech, MAR.
Mohamed El FadliMedical Oncology, Faculty of Medicine and Pharmacy of Marrakech, Cadi Ayyad University, Marrakech, MAR.
Leila AfaniOncology, Mohammed VI University Hospital of Marrakech, Marrakech, MAR.
Rhizlane BelbarakaMedical Oncology, Mohammed VI University Hospital of Marrakech, Marrakesh, MAR.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sebaceous carcinoma of the breast is a rare and poorly understood variant of metaplastic breast carcinoma. Its histogenesis, clinical behavior, and optimal management remain unclear due to the limited number of reported cases. We report the case of a 78-year-old woman presenting with a six-month history of a right axillary mass and inflammatory changes in the right breast. Clinical and radiologic assessments indicated an advanced-stage lesion. Histological analysis from a core needle biopsy revealed solid nests and tubules with sebaceous differentiation. Immunohistochemistry confirmed a triple-negative profile, with high proliferative activity. The patient received neoadjuvant chemotherapy without clinical improvement. Disease progression was noted despite a switch to a platinum-based regimen, followed by further deterioration after additional treatment. The patient was eventually lost to follow-up. This case highlights the aggressive nature and treatment resistance of this carcinoma and underscores the need for further investigation to better define its characteristics and guide therapeutic strategies.

Indexed as

chemoresistanceimmunohistochemistrmetastaticprimary breast neoplasmsebaceous carcinoma of the breast

Identifiers

PMID40918903
PMCPMC12410994

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.