ArticleCureus2025
A Rare Presentation of Acute Generalized Exanthematous Pustulosis With Refractory Shock.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
5 authors.
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Abstract
Acute generalized exanthematous pustulosis (AGEP) is a severe cutaneous adverse reaction that presents with pustular lesions with underlying edematous and erythematous skin, accompanied by fever, leukocytosis, and neutrophilia. It is characterized by an abrupt onset, usually 24-48 hours after the inciting trigger. The incidence of AGEP is an uncommon skin reaction that is primarily seen in female patients. The clinical course is mostly limited to cutaneous findings, and only in rare cases, systemic involvement can occur. AGEP typically resolves within 1-2 weeks after discontinuation of the offending agent, and topical steroids are used for symptomatic relief. In more severe cases, systemic corticosteroids, vasopressors, or cyclosporine are useful, and vasopressors may be required in cases of circulatory shock. In this case, we present a middle-aged woman with fluid nonresponsive circulatory shock and acute kidney injury secondary to an uncommon presentation of AGEP, confirmed by histopathologic findings.
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