Evidence map›Paper›PMID 40918648›Full record

ArticleNAR cancer2025

Inherent single-cell heterogeneity of the transcriptional response to hypoxia in cancer cells.

Małgorzata Wilk, Thomas Knöpfel, Stana M Burger, Stellor Nlandu Khodo, Roland H Wenger

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NAR cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Małgorzata WilkInstitute of Physiology, University of Zürich, Zürich, CH-8057, Switzerland.
Thomas KnöpfelInstitute of Physiology, University of Zürich, Zürich, CH-8057, Switzerland.
Stana M BurgerInstitute of Physiology, University of Zürich, Zürich, CH-8057, Switzerland.
Stellor Nlandu KhodoInstitute of Physiology, University of Zürich, Zürich, CH-8057, Switzerland.
Roland H WengerInstitute of Physiology, University of Zürich, Zürich, CH-8057, Switzerland.ORCID 0000-0001-7592-4839

Funding

Swiss National Science Foundation 310030_184813 AND 310030_219198
6 · The paper itself

Abstract

Hypoxia-inducible factor (HIF) is a master regulator of cancer cell adaptation to tumor hypoxia and is involved in cancer progression. Single-cell (sc) differences in the HIF response allow for tumor evolution and cause therapy resistance. These sc-differences are usually ascribed to tumor microenvironmental differences and/or clonal (epi)genetic variability. However, the sc-heterogeneity of the HIF response in otherwise identical cells cultured under defined

Indexed as

Basic Helix-Loop-Helix ProteinsHypoxia-Inducible Factor 1, alpha SubunitNeoplasmsSingle-Cell AnalysisCell HypoxiaCell Line, TumorEndothelial PAS Domain-Containing Protein 1Gene Expression Regulation, NeoplasticHumansRNA, MessengerTranscription, GeneticTumor HypoxiaTumor MicroenvironmentBasic Helix-Loop-Helix ProteinsEndothelial PAS Domain-Containing Protein 1HIF1A protein, humanHypoxia-Inducible Factor 1, alpha SubunitRNA, Messenger

Identifiers

PMID40918648
PMCPMC12409416

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.