Evidence map›Paper›PMID 40918530›Full record

ArticleFrontiers in pharmacology2025

Cu

Sitong Lai, Kunhui Sun, Yun Wu, Xueyuan Wu, Yiqi Yan, Guojing Liu, Xiaoyi Liu, Yuanyuan Ge, Lina Zeng, Ziyu Guo and 5 more

Abstract read
In one paragraph

Article in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sitong Lai *Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Kunhui Sun *Institute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Yun WuShenzhen tsumura medicine Co., Ltd., Shenzhen, China.
Xueyuan WuJiangmen Institute for Drug Control, Jiangmen, China.
Yiqi YanInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Guojing LiuInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Xiaoyi LiuInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Yuanyuan GeShenzhen Institute for drug Control, Shenzhen, China.
Lina ZengShenzhen Institute for drug Control, Shenzhen, China.
Ziyu GuoShenzhen Institute for drug Control, Shenzhen, China.
Shuhong WangShenzhen Institute for drug Control, Shenzhen, China.
Ping WangShenzhen Institute for drug Control, Shenzhen, China.
Bing WangShenzhen Institute for drug Control, Shenzhen, China.
Han ZhangInstitute of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, China.
Xie-An YuShenzhen Institute for drug Control, Shenzhen, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The procedural complexity and time-consuming of conventional pesticide residue detection methods in traditional Chinese medicines (TCMs) significantly impeded their application in modern systems. To address this, this study presented an innovative dual-mode sensor driven by Cu Methods: The AB-Cu NPs sensor, a dynamic redox-responsive system, was constructed via coordination-driven assembly of Azo-Bodipy 685 (AB 685) and Cu Results: The sensor exhibited positive sensitivity with detection limits of 0.0327 U/L for AChE activity and 1.72 ng/mL for triazophos, leveraging Cu Discussion: This study developed a portable detection platform based on valence interconversion coupled enzyme inhibition with probe responsiveness. The dual-signal output enhanced reliability and the redox-driven mechanism enabled signal amplification. This advancement provided a real-time, portable and rapid detection for AChE activity and pesticide exposure of TCMs, bridging gaps in agricultural safety and pharmaceutical standardization.

Indexed as

acetylcholinesterasedual-mode sensororganophosphorus pesticidesredox-cycling-driventraditional Chinese medicines

Identifiers

PMID40918530
PMCPMC12411482

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.