Evidence map›Paper›PMID 40918460›Full record

ArticleOncology research2025

SORBS1 Knockdown Resists S/G2 Arrest and Apoptosis Caused by Polyphyllin H-Induced DNA Damage in Pancreatic Cancer.

Xinxin Hu, Yuye Xue, Fei Fang, Jie Li, Xiaofeng Yuan, Guang Cheng, Hailong Yuan, Yongqiang Zhang, Yuefei Zhou, Shuangwu Yang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncology research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Xinxin HuSchool of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, 712046, China.
Yuye XueDepartment of Pharmacy, Air Force Medical Center, PLA, The Fourth Military Medical University, Beijing, 100142, China.
Fei FangDepartment of Central Laboratory, The First Affiliated Hospital of Northwestern University, The First Hospital of Xi'an, Xi'an, 710069, China.
Jie LiDepartment of Chinese Materia Medica and Natural Medicines, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.
Xiaofeng YuanDepartment of Chinese Materia Medica and Natural Medicines, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.
Guang ChengDepartment of Neurosurgery, Xijing Institute of Clinical Neuroscience, The Fourth Military Medical University, Xi'an, 710032, China.
Hailong YuanDepartment of Pharmacy, Air Force Medical Center, PLA, The Fourth Military Medical University, Beijing, 100142, China.
Yongqiang ZhangDepartment of Chinese Materia Medica and Natural Medicines, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.
Yuefei ZhouDepartment of Neurosurgery, Xijing Institute of Clinical Neuroscience, The Fourth Military Medical University, Xi'an, 710032, China.
Shuangwu YangDepartment of Neurosurgery, Xijing Institute of Clinical Neuroscience, The Fourth Military Medical University, Xi'an, 710032, China.
Pengcheng QiuDepartment of Chinese Materia Medica and Natural Medicines, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.
Yunyang LuDepartment of Chinese Materia Medica and Natural Medicines, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.
Haifeng TangDepartment of Chinese Materia Medica and Natural Medicines, School of Pharmacy, The Fourth Military Medical University, Xi'an, 710032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: The Sorbin and SH3 domain containing 1 (SORBS1), a protein linked to insulin signaling CBL interaction, was investigated for its role in pancreatic cancer apoptosis. This study explored polyphyllin H (PPH)'s ability to restore SORBS1-knockdown-mediated repair functions. Methods: PANC-1 cells were divided into Blank, overexpression (OE), and knockdown groups. CCK-8 assays assessed proliferation and drug toxicity. Western blot and flow cytometry analyzed SORBS1 levels and PPH effects. Comet assays quantified DNA damage. Subcutaneous xenograft tumors in nude mice (Blank vs. knockdown) were treated with PPH to evaluate Results: PPH suppressed pancreatic cancer growth Conclusion: SORBS1 knockdown counteracts PPH-mediated S/G2 arrest and apoptosis by alleviating DNA damage in pancreatic cancer. These findings highlight SORBS1 as a critical modulator of PPH's therapeutic potential, linking its expression to chemoresistance mechanisms.

Indexed as

Adaptor Proteins, Signal TransducingDNA DamageG2 Phase Cell Cycle CheckpointsPancreatic NeoplasmsAnimalsApoptosisCell Line, TumorCell ProliferationFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesHumansMiceMice, NudePrognosisXenograft Model Antitumor AssaysAdaptor Proteins, Signal Transducingdrug resistanceNatural productsaponintumor

Identifiers

PMID40918460
PMCPMC12408846

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.