Evidence map›Paper›PMID 40918420›Full record

ArticleNpj complexity2025

Assembly theory and its relationship with computational complexity.

Christopher P Kempes, Michael Lachmann, Andrew Iannaccone, G Matthew Fricke, M Redwan Chowdhury, Sara I Walker, Leroy Cronin

Abstract read
In one paragraph

Article in Npj complexity, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Rapid Exploration of the Assembly Chemical Space of Molecular Graphs.Journal of chemical information and modeling · 2025
    Article
  2. Origins of life: the possible and the actual.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christopher P KempesThe Santa Fe Institute, Santa Fe, NM USA.
Michael LachmannThe Santa Fe Institute, Santa Fe, NM USA.
Andrew IannacconeComputer Science, University of New Mexico, Albuquerque, NM USA.
G Matthew FrickeComputer Science, University of New Mexico, Albuquerque, NM USA.
M Redwan ChowdhuryBEYOND Center for Fundamental Concepts in Science, Arizona State University, Tempe, AZ USA.
Sara I WalkerThe Santa Fe Institute, Santa Fe, NM USA.
Leroy CroninThe Santa Fe Institute, Santa Fe, NM USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Assembly theory (AT) quantifies selection using the assembly equation, identifying complex objects through the assembly index, the minimal steps required to build an object from basic parts, and copy number, the observed instances of the object. These measure a quantity called Assembly, capturing causation necessary to produce abundant objects, distinguishing selection-driven complexity from random generation. Unlike computational complexity theory, which often emphasizes minimal description length via compressibility, AT explicitly focuses on the causation captured by selection as the mechanism behind complexity. We illustrate formal distinctions through mathematical examples demonstrating that the assembly index is fundamentally distinct from complexity metrics like Shannon entropy, Huffman encoding, and Lempel-Ziv-Welch compression. We provide proofs showing that the assembly index belongs to a different computational complexity class compared to these measures and compression algorithms. Additionally, we highlight AT's unique ontological grounding as a physically measurable framework, setting it apart from abstract theoretical approaches to formalizing life that lack empirical measurement foundations.

Indexed as

AstrobiologyInformation theory and computationOrigin of life

Identifiers

PMID40918420
PMCPMC12408342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.