Evidence map›Paper›PMID 40918248›Full record

ArticleIDCases2025

Orthopnea as a trigger for a diagnostic cascade of multiple infectious diseases.

Marcus Bauer, Anke Hildebrandt

Abstract readCase Reports
In one paragraph

Article in IDCases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Marcus BauerDepartment of Internal Medicine II, St. Vincenz-Krankenhaus Datteln, Datteln, Germany.
Anke HildebrandtInstitute of Medical Microbiology, University Hospital Münster, Münster, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Dyspnea is a common clinical symptom and cause of outpatient and inpatient presentations to the clinic. Diagnostic and therapeutic challenges appear, when additional diseases appear that are themselves associated with subjectively perceptible dyspnea. We report on a young woman with orthopnea as a trigger of a diagnostic cascade of various diseases. Case presentation: A 34-year-old woman presented to our emergency department with breathing-dependent, burning thoracic pain, purulent sputum and hemoptysis for three days. Pre-existing diagnoses were psoriasis vulgaris and diabetes mellitus (type 2). Human monoclonal antibody secukinumab and methotrexate were regular drugs.We suspected a community-acquired pneumonia or bacterial co-infection of acute COVID-19. A bronchoalveolar lavage (BAL) led to the detection of Conclusions: Immunosuppression can lead to several associated infectious diseases. Before starting anti-TNF or anti-interleukin therapy, latent tuberculosis must always be ruled out. The need for cortisone therapy in immunocompromised people with COVID-19 disease must be evaluated.

Indexed as

Antibody therapyCOVID-19DyspneaLiver toxicityMRSAPneumocystis jiroveciiPulmonary tuberculosis

Identifiers

PMID40918248
PMCPMC12409317

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.