ArticlePain reports2025
The maturation of spinal dorsal horn nociceptive neuronal network activity over the postnatal period.
Article in Pain reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: The dorsal horn (DH) of the spinal cord is physiologically immature at birth. Spinal excitability increases and wide dynamic range (WDR) neurons in lamina V have lowered activation thresholds and larger receptive field sizes. Objective: The DH is composed of 5 laminae containing diverse interneuronal populations yet our understanding of the physiology of the DH is based on behavioural studies or extrapolation of single cell WDR recordings to the whole network. Methods: We have employed multi-electrode arrays to record contiguous activity across the whole DH in neonatal juvenile, adolescent, and young adult Sprague-Dawley rats after electrical stimulation of the ipsilateral hindpaw (0.01-5 mA). Results: Baseline DH activity increased significantly ( Conclusion: Despite behavioural and single-cell responses being more excitable in early life, at a network level the DH is significantly less excited than in adulthood.
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