Evidence map›Paper›PMID 40918188›Full record

ArticleFrontiers in cardiovascular medicine2025

Prognostic significance of FT3 levels in hypertrophic cardiomyopathy patients with HFpEF.

Zhen-Yu Yang, Zhi-Yuan Zhang, Wei-Jie Zhang, Da Liu, Fu-Shi Piao, Xiangyu Yan, Fang-Tao Shi, Min Yang, Jing Chen, Sheng-Song Zhu and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cardiovascular medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zhen-Yu Yang *Cardiac Surgery Department, The Peoplès Hospital of Anyang City, Anyang, Henan, China.
Zhi-Yuan Zhang *Department of Plastic and Burn Surgery, National Key Clinical Construction Specialty, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Wei-Jie Zhang *Department of Cardiology, the First Hospital of Hebei Medical University, Graduate School of Hebei Medical University, Shijiazhuang, Hebei, China.
Da LiuShenzhen Third People's Hospital, Shenzhen, China.
Fu-Shi PiaoDepartment of Cardiology, Peking University Shenzhen Hospital, Shenzhen, China.
Xiangyu YanInstitute of Disaster and Emergency Medicine, Tianjin University, Tianjin, China.
Fang-Tao ShiCardiac Surgery Department, The Peoplès Hospital of Anyang City, Anyang, Henan, China.
Min YangDepartment of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Jing ChenDepartment of Cardiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Sheng-Song ZhuInstitute of Disaster and Emergency Medicine, Tianjin University, Tianjin, China.
Hong-Hou HeDepartment of Cardiology, the First Hospital of Hebei Medical University, Graduate School of Hebei Medical University, Shijiazhuang, Hebei, China.
Pei-Hong WuDepartment of Cardiology, the First Hospital of Hebei Medical University, Graduate School of Hebei Medical University, Shijiazhuang, Hebei, China.
Cheng QianDepartment of Cardiology and Institute of Vascular Medicine, Peking University Third Hospital, Beijing, China.
Min LinDivision of Cardiac Arrhythmia, Cardiac and Vascular Center, The University of Hong Kong-Shenzhen Hospital, Shenzhen, Guangdong, China.
Jun-Qing FengCardiac Surgery Department, The Peoplès Hospital of Anyang City, Anyang, Henan, China.
Chun-Jin LaiDepartment of Cardiology, Dongguan Tai-xin Hospital, Dongguan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study sought to identify key prognostic factors in patients with hypertrophic cardiomyopathy (HCM) and heart failure with preserved ejection fraction (HFpEF), emphasizing the prognostic role of free triiodothyronine (FT3) levels. Research design and methods: This retrospective cohort study enrolled 992 HCM-HFpEF patients from two Chinese medical centers between 2009 and 2019, excluding those with thyroid-affecting medications or disorders. Data on demographic and clinical variables, including FT3, were analyzed using univariate and multivariate Cox regression, Kaplan-Meier (KM) survival analysis, and restricted cubic spline (RCS) analysis to explore prognostic factors and FT3's nonlinear predictive value. Results: Age, atrial fibrillation, and NT-proBNP levels significantly influenced prognosis, while FT3 emerged as an independent predictor of all-cause mortality and cardiac transplantation ( Conclusions: FT3 is a robust prognostic marker in HCM-HFpEF patients, supporting its integration into risk stratification. Clinicians should monitor FT3 levels, though intervention efficacy requires further prospective validation.

Indexed as

all-cause mortalitycardiac transplantationFT3HCM-HFpEFnon-linear analysisprognosisthyroid function

Identifiers

PMID40918188
PMCPMC12408591

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.