ReviewFrontiers in immunology2025
Leukocyte recruitment in flavivirus-induced encephalitis.
Review in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- CSF Leukocytes in Intracranial Infections: Diagnostic, Mechanistic, and Therapeutic Insights for Neurocritical Care.Cellular and molecular neurobiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flaviviruses are capable of causing a myriad of diseases in humans, including viral encephalitis. This condition involves complex interactions between the virus, resident cells of the central nervous system and leukocytes recruited to the brain. We reviewed the mechanisms underlying leukocyte recruitment during flavivirus-induced encephalitis with a focus on the role of various chemoattractants and adhesion molecules. We discuss how these molecules orchestrate the migration of peripheral leukocytes into the brain parenchyma and how neurotropic flaviviruses induce this process. Moreover, we discuss evidence of leukocytes both controlling viral propagation and contributing to neuropathology, which poses a challenge for therapy development. This review summarizes our current understanding of the mechanisms behind leukocyte recruitment during encephalitis, addresses the gaps that remain in the field, and presents opportunities for therapeutic targeting unveiled by recent research on flaviviral encephalitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.