Observational studyFrontiers in immunology2025
Antibodies against integrin αvβ6 have high diagnostic accuracy for ulcerative colitis.
Observational study in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Coincident epithelial signals restrain commensal-specific CD8αβbioRxiv : the preprint server for biology · 2026Article
- UC-associated autoantibodies to αvβ6 inhibit mucosal TGFβ activation and predispose to intestinal inflammation.bioRxiv : the preprint server for biology · 2026Article
- Clinical Value of Anti-Integrin αvβ6 Antibody Serum-Level Measurement in Inflammatory Bowel Diseases.Journal of clinical medicine · 2026Article
- Serological Remission Defined by Anti-Integrin αvβ6 Antibody Predicts Long-Term Clinical Remission of Ulcerative Colitis.Gastro hep advances · 2026Article
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Authors and funding
22 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Anti-integrin αvβ6 IgG autoantibodies showed good sensitivity and optimal specificity in ulcerative colitis (UC) compared to controls. We aim at confirming the diagnostic accuracy of anti-integrin αvβ6 autoantibodies in an Italian multicentric cohort. Methods: This observational multicentric study included adult and pediatric patients with inflammatory bowel disease and controls. Data on demographics, disease extension, partial Mayo score, fecal calprotectin, endoscopic Mayo score, and the time to the composite outcome including hospitalization or colectomy were collected. A new commercial ELISA kit was used to measure anti-integrin αvβ6 in the serum of the enrolled patients. Receiver operating curve (ROC) was used to identify the optimal cutoff to discriminate UC cases from other patients. Kaplan-Meier curves and log-rank test were used to analyze the composite outcome hospitalization and need of colectomy. Results: A total of 228 patients were enrolled, including 36 controls (13 healthy donors and 24 diseased controls), 34 irritable bowel syndrome (IBS) patients, 50 Crohn's disease (CD) patients, and 107 UC patients. The UC patients presented higher values of anti-integrin αvβ6 IgG compared to CD, IBS, and controls (Kruskal-Wallis test and Conclusions: This study validates a new anti-integrin αvβ6 ELISA kit and confirms its high diagnostic accuracy in UC also in a European population, with particular utility in the differential diagnosis of specific forms of IBD.
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