Evidence map›Paper›PMID 40917984›Full record

ArticleBMJ neurology open2025

Evaluation of outcomes for patients with nitrous oxide-related myeloneuropathy treated with self-injection of hydroxocobalamin versus nurse-led injections on an ambulatory care pathway.

Mohamoud Hashi, Laura Smith, Marta Patyjewicz, Barbara Onen, Katrina Mamigo, Eunice Adu-Poku, Gillian Fox, Alastair J Noyce

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ neurology open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Mohamoud HashiWolfson Institute of Population Health, Queen Mary University of London, Centre for Preventive Neurology, London, England, UK.ORCID https://orcid.org/0009-0000-6112-4830
Laura SmithWolfson Institute of Population Health, Queen Mary University of London, Centre for Preventive Neurology, London, England, UK.
Marta PatyjewiczWolfson Institute of Population Health, Queen Mary University of London, Centre for Preventive Neurology, London, England, UK.
Barbara OnenDepartment of Neuology, Royal London Hospital, Barts Health NHS Trust, London, England, UK.
Katrina MamigoDepartment of Neuology, Royal London Hospital, Barts Health NHS Trust, London, England, UK.
Eunice Adu-PokuDepartment of Neuology, Royal London Hospital, Barts Health NHS Trust, London, England, UK.
Gillian FoxDepartment of Neuology, Royal London Hospital, Barts Health NHS Trust, London, England, UK.
Alastair J NoyceWolfson Institute of Population Health, Queen Mary University of London, Centre for Preventive Neurology, London, England, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Nitrous oxide (N₂O)-related neurotoxicity is a significant public health concern among young people in the UK. Recognition necessitates timely diagnosis, abstinence from N₂O consumption and replacement of vitamin B12, usually via intramuscular (IM) hydroxocobalamin. This service development project evaluated a self-injection programme (SIP) compared with a nurse-led approach, within an established ambulatory care pathway, with the aim of improving treatment adherence and completion. Methods: Between June and December 2024, a total of 46 patients presenting with N₂O-induced neurological symptoms were included in the evaluation. Patients were given the choice of self-injecting (SIP, n=25) or attending the hospital for nurse-led administration (non-SIP, n=21). Clinical outcomes, adherence and functional improvement (including the 10 metre walk test (10MWT)) were assessed. Results: Most patients were young (median age of 23), male (n=29, 63%), of Asian or Asian British ethnicity (n=29, 63%), and regularly using N Conclusion: Self-injection of IM hydroxocobalamin is a feasible and likely cost-effective alternative to nurse-led administration while maintaining clinical efficacy.

Indexed as

B12 DEFICIENCYNEUROPATHYNEUROTOXICOLOGY

Identifiers

PMID40917984
PMCPMC12410673

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.