ReviewCureus2025
The Utility of Troponin in Predicting Cardiac Dysfunction in Pediatric Patients: A Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the management of adults, troponins are routinely used to detect acute coronary syndrome and to predict increased risk of mortality. However, there is limited information available on the utility of troponin for risk assessment in children with chest pain. This study aimed to investigate whether elevated troponin in pediatric patients (0-21 years of age, as per guidelines during the sampling timeframe) presenting with chest pain has a role as a prognostic biomarker for myocardial dysfunction. In a systematic review and meta-analysis, searches were scoped with language restriction to English on PubMed and Cochrane from their inception to 2023. Evidence included studies reporting the association of elevated troponin with myocardial dysfunction. A summary of odds ratios for the association of elevated troponin with myocardial dysfunction was generated. The Quality in Prognosis Studies tool was used to assess methodological quality. Six studies involving 3,144 patients presenting with chest pain were included in the analysis. The risk of myocardial dysfunction was greater in subjects with elevated troponin than in those without (odds ratio, 3.30; 95% confidence interval, 2.19-4.40). Considerable interstudy heterogeneity (I
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