ArticleiScience2025
Enriched environment requires the remodeling of hippocampal perineuronal nets to trigger memory improvement in Alzheimer's mouse model.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- ALS mutations do not alter perineuronal net formation in human stem cell-derived motor neurons.Communications biology · 2026Article
- The hippocampal subgranular zone neurogenic niche: a modular perspective on neural stem cell regulation.Frontiers in cellular neuroscience · 2026Review
- Critical Periods and Beyond: Dynamic Functions of Perineuronal Nets in Cognition, Development, and Disease.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
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Authors and funding
5 authors.
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Abstract
Alzheimer's disease (AD) is a major neurodegenerative disorder influenced by both genetic and environmental factors. Mentally stimulating activities are believed to reduce cognitive decline by establishing a cognitive reserve, although the underlying neurobiological mechanisms remain elusive. In this study, we investigate the role of parvalbumin-expressing inhibitory neurons (PV+) and their perineuronal nets (PNN) in the establishment of cognitive reserve using a mouse model of AD. We demonstrate that 10 days in an enriched environment (EE) significantly restores both spatial and social memory, which is accompanied by an increase in PV+ and PV+/PNN+ cells in the hippocampus. Notably, preventing PV/PNN remodeling in CA1 during EE abolishes the spatial memory improvements, whereas localized neuregulin-1 (NRG1) injections induce PV/PNN remodeling and restore memory performance. These findings indicate that hippocampal PV/PNN remodeling is a key contributor to the cognitive benefits of EE in AD, highlighting this neuronal population as a substrate for cognitive reserve.
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