ArticleFrontiers in physiology2025
Electrical impedance tomography-based temporal signals correlate with quantitative computed tomography-based spatial variables in asthma subjects: a pilot study.
Article in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Quantitative computed tomography (qCT) provides detailed spatial assessments of lung structure and function, while electrical impedance tomography (EIT) offers high temporal resolution for analyzing breathing patterns but lacks structural detail. This study investigates the correlation between qCT-based spatial variables and EIT-based temporal signals to elucidate the physiological relationships between these two modalities. Methods: Six participants with asthma underwent pulmonary function tests (PFTs) before and after bronchodilator inhalation. CT scans were obtained in full inhalation and normal exhalation, providing airway hydraulic luminal diameter ( Results: High-frequency EIT values in the upper lungs were associated with a decline of lung function in pre-bronchodilator. Skewness values, measured by an imbalance between exhalation and inhalation, was elevated in the upper lungs and correlated with impaired lung function. Besides, Conclusion: EIT temporal signals demonstrated significant associations with spatial metrics from CT images, as well as PFTs metrics. A frequency analysis of EIT may enhance diagnostic approaches and improve understanding of respiratory mechanics in subjects with asthma.
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